The image shows a portion of the mouse corpus callosum 10 days after focal demyelination by injection with lysolecithin. The mouse was treated with the pro-remyelinating, selective estrogen receptor modulator bazedoxifene, and it shows clear remyelination, as indicated by immunostaining for myelin oligodendrocyte glycoprotein (green) and increased numbers of oligodendrocytes (red) within the lesion borders. Cell nuclei were identified by DAPI (blue). For more information, see article by Rankin et al. (pages 2184–2194).