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Journal of Neuroscience, Vol 1, 1242-1259, Copyright © 1981 by Society for Neuroscience
An autoradiographic study of the projections of the central nucleus of the monkey amygdala
JL Price and DG Amaral
The efferent connections of the central nucleus of the monkey amygdala have
been studied using the autoradiographic method for tracing axonal
projections. Small injections of 3H-amino-acids which are largely confined
to the central nucleus lead to the labeling of several brainstem nuclei as
far caudally as the spinomedullary junction. Specifically, in the
forebrain, the central nucleus projects heavily to the bed nucleus of the
stria terminalis, the basal nucleus of Meynert, the nucleus of the
horizontal limb of the diagonal band, and more lightly to the substantia
innominata and the preoptic area. In the hypothalamus, label is found over
the dorsomedial nucleus, the perifornical region, the lateral hypothalamus,
the supramammillary area, and most heavily in the paramammillary nucleus.
In the thalamus, all components of the nucleus centralis medialis and the
nucleus reuniens receive fibers from the central nucleus and there is a
light projection to the medial pulvinar nucleus. In the mesencephalon,
there is heavy labeling dorsal to the substantia nigra ad over the
peripeduncular nucleus and lighter labeling within the substantia nigra
pars compacta and the ventral tegmental area; the midbrain central gray is
also labeled. More caudally, fibers from the central nucleus travel in the
lateral tegmental reticular fields and contribute collaterals to the raphe
nuclei, the cuneiform nucleus, and the central gray substance. Perhaps one
of the heaviest terminal zones is the parabrachial region of the pons, both
the lateral and the medial nuclei of which receive a prominent central
nucleus projection. Only the ventral aspect of the adjacent locus coeruleus
appears to receive a substantial input, but there is labeling also over the
area of the nucleus subcoeruleus. Finally, there is heavy labeling around
the dorsal motor nucleus of the vagus and over the parvocellular component
of the nucleus of the solitary tract. A number of intra-amygdaloid
connections between the basal and lateral nuclei of the amygdala and the
central nucleus are also described. The present findings, taken together
with recently reported widespread projections from the temporal association
cortex to the amygdala, point out a potentially trisynaptic route between
neocortical association regions and a variety of brainstem nuclei, many of
which are related to autonomic function.
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