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Journal of Neuroscience, Vol 1, 532-547, Copyright © 1981 by Society for Neuroscience
Glycine receptor: light microscopic autoradiographic localization with [3H]strychnine
MA Zarbin, JK Wamsley and MJ Kuhar
Glycine receptors have been localized by autoradiography in the rat central
nervous system (CNS) using [3H]strychnine. The gross distribution of
receptors is in excellent accord with the distribution determined by
filtration binding assays. Specifically, the density of glycine receptors
is greatest in the gray matter of the spinal cord and decreases
progressively in regions more rostral in the neuraxis. Glycine receptors
were found to be associated with both sensory and motor systems in the CNS.
Moreover, there is a striking correlation between areas of high strychnine
binding site density and areas in which glycine has been found to be
electrophysiologically active. Finally, the anatomic localization of
strychnine binding sites may help explain many of the signs and symptoms of
strychnine ingestion. For example, individuals consuming subconvulsive
doses of strychnine frequently experience altered cutaneous and auditory
sensation. We have localized strychnine receptors in areas of the acoustic
system known to influence discriminative aspects of audition and in areas
of the spinal cord and trigeminal nuclei which modulate discriminative
aspects of cutaneous sensation. The alteration of visceral functions (e.g.,
blood pressure and respiratory rate) associated with strychnine ingestion
may be accounted for in a similar manner.
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