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Journal of Neuroscience, Vol 10, 153-160, Copyright © 1990 by Society for Neuroscience
Expression of myosin heavy chain isoforms in stimulated fast and slow rat muscles
S Ausoni, L Gorza, S Schiaffino, K Gundersen and T Lomo
Institute of General Pathology, University of Padova, Italy.
The expression of 4 myosin heavy chain (MHC) isoforms was analyzed in the
rat soleus (SOL) and extensor digitorum longus (EDL) muscles after
denervation and chronic electric stimulation. The stimulation frequencies
used were 20 and 150 Hz and the amount of stimulation was either large (20
Hz), intermediate (150 Hz), or small (150 Hz). These patterns resemble some
features of normal motor unit activity in SOL and EDL of freely moving rats
(Hennig and Lomo, 1985). The relative expression of each MHC isoform
depended strongly on the stimulation pattern. Furthermore, for any
particular stimulation pattern, fibers in SOL and EDL expressed different
MHCs. Coexistence of different MHC types in the same fiber was frequently
observed in stimulated muscles. 20-Hz stimulation preserved normal
expression of type 1-MHC in SOL but failed to induce type 1-MHC in type 2
fibers of the EDL, where type 2A- and 2X-MHC expression dominated and type
2B-MHC expression was completely suppressed. 150-Hz low-amount stimulation
preserved nearly normal 2B-MHC expression in many type 2 fibers of the EDL
but failed to induce type 2B-MHC expression in the SOL, where 2X-MHC became
predominant. 150-Hz high-amount stimulation differed from 150-Hz small
amount stimulation by suppressing almost all type 2B-MHC expression in EDL
and by inducing considerable type 2A-MHC expression in the SOL. Scattered
fibers in EDL that were probably the original type 1 fibers responded
differently from both type 2 fibers in the EDL and from type 1 fibers in
the SOL to stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)
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