QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (22) Citing Articles via Google Scholar Google Scholar Articles by Watson, D. F. Articles by Griffin, J. W. Search for Related Content PubMed PubMed Citation Articles by Watson, D. F. Articles by Griffin, J. W.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 10, 3344-3352, Copyright © 1990 by Society for Neuroscience

ARTICLE

The cold stability of microtubules increases during axonal maturation

DF Watson, PN Hoffman and JW Griffin
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

The development of cold-stable microtubules (MTs) was studied in maturing rat sciatic nerves. From 4 to 10 weeks of age, there was a large increase in the proportion of tubulin associated with stable MTs. A greater fraction of axonal tubulin than nonaxonal tubulin was associated with stable MTs. The labeled tubulin remaining behind the peak of slow axonal transport was more highly associated with stable MTs than tubulin in the peak itself. Immunoassay confirmed that the sciatic nerve contains a pool of stable MTs not identical to the peak of tubulin transport. The developmental increase in MT stability is not associated with any increase in the acetylation of tubulin or with alterations in the major MT-associated proteins. One aspect of maturation of the axonal cytoskeleton may involve deposition of tubulin into stable MTs that are either stationary or moving slowly with regard to the peak of transported tubulin.

This article has been cited by other articles:

				M. K. E. Schaefer, H. Schmalbruch, E. Buhler, C. Lopez, N. Martin, J.-L. Guenet, and G. Haase Progressive Motor Neuronopathy: A Critical Role of the Tubulin Chaperone TBCE in Axonal Tubulin Routing from the Golgi Apparatus J. Neurosci., August 15, 2007; 27(33): 8779 - 8789. [Abstract] [Full Text] [PDF]

				P. Baas, T. Pienkowski, K. Cimbalnik, K Toyama, S Bakalis, F. Ahmad, and K. Kosik Tau confers drug stability but not cold stability to microtubules in living cells J. Cell Sci., January 1, 1994; 107(1): 135 - 143. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help