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Journal of Neuroscience, Vol 10, 3421-3438, Copyright © 1990 by Society for Neuroscience
Projection subtypes of rat neostriatal matrix cells revealed by intracellular injection of biocytin
Y Kawaguchi, CJ Wilson and PC Emson
Laboratory for Neural Systems, Frontier Research Program, RIKEN, Wako, Japan.
Individual neostriatal-matrix spiny neurons were stained intracellularly
with biocytin after intracellular recording in vivo, and their axons were
traced into the globus pallidus (GP), entopeduncular nucleus (EP), and/or
substantia nigra (SN). The locations of the neurons within the matrix
compartment of the neostriatum (NS) were established by immunocytochemical
counterstaining of sections containing the cell bodies using antibodies for
calbindin- D28K. This allowed nearly complete visualization of the axonal
projections of single NS neurons. On the basis of their intrastriatal
axonal arborizations, matrix spiny neurons could be divided into 2 types.
One type, which was the more common, had local axonal arborizations
restricted to the region of the dendritic field, often with axon
collaterals arborizing within the dendritic field of the cells of origin. A
second, less common, cell type in the matrix had local axon collaterals
distributed widely in the NS. Among matrix neurons with restricted local
collateral fields, 3 subtypes could be distinguished on the basis of their
efferent axonal projections. Type I cells projected only to the GP. Type
IIa cells projected to the GP, EP, and SN pars reticulata. Type IIb cells
projected to the GP and SN but not to the EP. The shapes and densities of
the GP arborizations varied in the 3 cell types, with the cells projecting
only to the GP (type I) projecting more heavily and filling a larger volume
there than type II cells. The dendrites and intrastriatal axon collaterals
of 3 subtypes were similar in morphology. The class of matrix spiny neurons
with intrastriatal axon collaterals distributed widely in the NS were
observed to project to the GP. Projections beyond the GP were not
identified for this cell type, but could not be ruled out. Somatodendritic
morphologies of neurons did not differ according to the projection site.
These results demonstrate that NS matrix spiny cells are more heterogeneous
in their efferent projection patterns than previously suspected on the
basis of retrograde axonal tracing and immunocytochemical studies. As
predicted by those previous studies, there is a class of matrix neurons
that projects only to the GP. Presumably, these cells contain enkephalin.
Cells projecting to the SN and EP, and so presumably containing substance
P, give off a small projection to the GP, as well, and differ in their
collateralization patterns within the 3 major target nuclei.
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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18(23):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Churchill, M. A. Klitenick, and P. W. Kalivas
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Kincaid, T. Zheng, and C. J. Wilson
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June 15, 1998;
18(12):
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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January 1, 1998;
18(1):
266 - 283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bontempi and F. R. Sharp
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J. Neurosci.,
November 1, 1997;
17(21):
8596 - 8612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Berretta, H. B. Parthasarathy, and A. M. Graybiel
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June 15, 1997;
17(12):
4752 - 4763.
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[Full Text]
[PDF]
|
|
|
|
|
|
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D. J. Surmeier, W.-J. Song, and Z. Yan
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October 15, 1996;
16(20):
6579 - 6591.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gerfen, T. Engber, L. Mahan, Z Susel, T. Chase, F. Monsma Jr, and D. Sibley
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Science,
December 7, 1990;
250(4986):
1429 - 1432.
[Abstract]
[PDF]
|
|
|
|
