 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 10, 3685-3694, Copyright © 1990 by Society for Neuroscience
Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains
WJ Schwartz and P Zimmerman
Department of Neurology, University of Massachusetts Medical School, Worcester 01655.
Circadian rhythms of locomotion (wheel-running activity) in 12 inbred mouse
strains were recorded for interstrain differences in tau DD, the endogenous
(free-running) period of the circadian pacemaker measured in constant
environmental darkness. The results indicate that 1 or more genetic loci
influence the value of tau DD, and a large (50 min) difference in mean tau
DD between 2 of the strains, BALB/cByJ and C57BL/6J, allowed further
characterization of the origins and inheritance of the polymorphic
expression of this circadian pacemaker property. The interstrain difference
in mean tau DD was associated with an interstrain difference in
light-induced shifts of the phase of the free-running locomotor rhythm; the
BALB/c strain (with the shorter mean tau DD) displayed relatively fewer
advance phase shifts. Neither the history of previous light exposure,
albinism, nor elevated circulating testosterone levels could account for
the interstrain difference in mean tau DD. The value of tau DD based on the
circadian rhythm of drinking activity (with the running wheel removed) was
longer than that based on locomotion; this discrepancy was significantly
greater and more variable in BALB/c than in C57BL/6 mice, though the
interstrain difference in mean tau DD could not be attributed entirely to
this effect. Reciprocal F1 hybrids of BALB/c x C57BL/6 matings revealed
dominance of the C57BL/6 genotype, no sex linkage, and a significant (but
small) maternal effect. Examination of CXB recombinant inbred strains
provided no support for the hypothesis of monogenic inheritance. Further
study of inherited differences in the BALB/c and C57BL/6 strains may be a
useful noninvasive experimental approach for investigation of the
neurobiological substrates of circadian rhythmicity.
This article has been cited by other articles:
|
|
|
|
 
J. Mendoza, P. Pevet, and E. Challet
High-fat feeding alters the clock synchronization to light
J. Physiol.,
December 15, 2008;
586(24):
5901 - 5910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Chen, D.-o. Seo, E. Bell, C. von Gall, and C. Lee
Strong Resetting of the Mammalian Clock by Constant Light Followed by Constant Darkness
J. Neurosci.,
November 12, 2008;
28(46):
11839 - 11847.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.T.L. Hughes and H.D. Piggins
Behavioral Responses of Vipr2-/- Mice to Light
J Biol Rhythms,
June 1, 2008;
23(3):
211 - 219.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. I. Masana, I. C. Sumaya, M. Becker-Andre, and M. L. Dubocovich
Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout
Am J Physiol Regulatory Integrative Comp Physiol,
June 1, 2007;
292(6):
R2357 - R2367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Yan, J. M. Bobula, P. Svenningsson, P. Greengard, and R. Silver
DARPP-32 Involvement in the Photic Pathway of the Circadian System
J. Neurosci.,
September 13, 2006;
26(37):
9434 - 9438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Vitaterna, C. H. Ko, A.-M. Chang, E. D. Buhr, E. M. Fruechte, A. Schook, M. P. Antoch, F. W. Turek, and J. S. Takahashi
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude
PNAS,
June 13, 2006;
103(24):
9327 - 9332.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Sollars, M. D. Ogilvie, A. M. Simpson, and G. E. Pickard
Photic Entrainment Is Altered in the 5-HT1B Receptor Knockout Mouse
J Biol Rhythms,
February 1, 2006;
21(1):
21 - 32.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. J. Chiesa, M. Angles-Pujolras, A. Diez-Noguera, and T. Cambras
Activity rhythm of golden hamster (Mesocricetus auratus) can be entrained to a 19-h light-dark cycle
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2005;
289(4):
R998 - R1005.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Brzezinski IV, N. L. Brown, A. Tanikawa, R. A. Bush, P. A. Sieving, M. H. Vitaterna, J. S. Takahashi, and T. Glaser
Loss of Circadian Photoentrainment and Abnormal Retinal Electrophysiology in Math5 Mutant Mice
Invest. Ophthalmol. Vis. Sci.,
July 1, 2005;
46(7):
2540 - 2551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mendoza, C. Graff, H. Dardente, P. Pevet, and E. Challet
Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle
J. Neurosci.,
February 9, 2005;
25(6):
1514 - 1522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Aton, G. D. Block, H. Tei, S. Yamazaki, and E. D. Herzog
Plasticity of Circadian Behavior and the Suprachiasmatic Nucleus Following Exposure to Non-24-Hour Light Cycles
J Biol Rhythms,
June 1, 2004;
19(3):
198 - 207.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. N. van Gelder and J. B. Hogenesch
Clean Thoughts about Dirty Genes
J Biol Rhythms,
February 1, 2004;
19(1):
3 - 9.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. R. Hofstetter, J. A. Trofatter, J. I. Nurnberger, K. L. Kernek, and A. R. Mayeda
New Quantitative Trait Loci for the Genetic Variance in Circadian Period of Locomotor Activity between Inbred Strains of Mice
J Biol Rhythms,
December 1, 2003;
18(6):
450 - 462.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Reinhold
Maternal Effects and the Evolution of Behavioral and Morphological Characters: A Literature Review Indicates the Importance of Extended Maternal Care
J. Hered.,
November 1, 2002;
93(6):
400 - 405.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Avivi, H. Oster, A. Joel, A. Beiles, U. Albrecht, and E. Nevo
Circadian genes in a blind subterranean mammal II: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspecies
PNAS,
September 3, 2002;
99(18):
11718 - 11723.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. G. Tankersley, R. Irizarry, S. Flanders, and R. Rabold
Functional Genomics of Sleep and Circadian Rhythm: Selected Contribution: Circadian rhythm variation in activity, body temperature, and heart rate between C3H/HeJ and C57BL/6J inbred strains
J Appl Physiol,
February 1, 2002;
92(2):
870 - 877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Shimomura, S. S. Low-Zeddies, D. P. King, T. D.L. Steeves, A. Whiteley, J. Kushla, P. D. Zemenides, A. Lin, M. H. Vitaterna, G. A. Churchill, et al.
Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice
Genome Res.,
June 1, 2001;
11(6):
959 - 980.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. P. Shearman, X. Jin, C. Lee, S. M. Reppert, and D. R. Weaver
Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function
Mol. Cell. Biol.,
September 1, 2000;
20(17):
6269 - 6275.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F.-Q. Liang, G. Allen, and D. Earnest
Role of Brain-Derived Neurotrophic Factor in the Circadian Regulation of the Suprachiasmatic Pacemaker by Light
J. Neurosci.,
April 15, 2000;
20(8):
2978 - 2987.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Best, E. S. Maywood, K. L. Smith, and M. H. Hastings
Rapid Resetting of the Mammalian Circadian Clock
J. Neurosci.,
January 15, 1999;
19(2):
828 - 835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. Solberg, T. H. Horton, and F. W. Turek
Circadian rhythms and depression: effects of exercise in an animal model
Am J Physiol Regulatory Integrative Comp Physiol,
January 1, 1999;
276(1):
R152 - R161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. von Gall, G. E. Duffield, M. H. Hastings, M. D. A. Kopp, F. Dehghani, H.-W. Korf, and J. H. Stehle
CREB in the Mouse SCN: A Molecular Interface Coding the Phase-Adjusting Stimuli Light, Glutamate, PACAP, and Melatonin for Clockwork Access
J. Neurosci.,
December 15, 1998;
18(24):
10389 - 10397.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Thresher, M. H. Vitaterna, Y. Miyamoto, A. Kazantsev, D. S. Hsu, C. Petit, C. P. Selby, L. Dawut, O. Smithies, J. S. Takahashi, et al.
Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses
Science,
November 20, 1998;
282(5393):
1490 - 1494.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. Linkowski, K. Spiegel, M. Kerkhofs, M. L'Hermite-Baleriaux, A. Van Onderbergen, R. Leproult, J. Mendlewicz, and E. Van Cauter
Genetic and environmental influences on prolactin secretion during wake and during sleep
Am J Physiol Endocrinol Metab,
May 1, 1998;
274(5):
E909 - E919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. S. Valentinuzzi, K. Scarbrough, J. S. Takahashi, and F. W. Turek
Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice
Am J Physiol Regulatory Integrative Comp Physiol,
December 1, 1997;
273(6):
R1957 - R1964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Shen, M. Watanabe, H. Tomasiewicz, U. Rutishauser, T. Magnuson, and J. D. Glass
Role of Neural Cell Adhesion Molecule and Polysialic Acid in Mouse Circadian Clock Function
J. Neurosci.,
July 1, 1997;
17(13):
5221 - 5229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. C. Davis and N. Viswanathan
The Effect of Transplanting One or Two Suprachiasmatic Nuclei on the Period of the Restored Rhythm
J Biol Rhythms,
December 1, 1996;
11(4):
291 - 301.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Benloucif and M. L. Dubocovich
Melatonin and Light Induce Phase Shifts of Circadian Activity Rhythms in the C3H/HeN Mouse
J Biol Rhythms,
June 1, 1996;
11(2):
113 - 125.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. J. Schwartz, R. V. Peters, N. Aronin, and M. R. Bennett
Unexpected c-fos Gene Expression in the Suprachiasmatic Nucleus of Mice Entrained to a Skeleton Photoperiod
J Biol Rhythms,
March 1, 1996;
11(1):
35 - 44.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.P. King and J.S. Takahashi
Forward Genetic Approaches to Circadian Clocks in Mice
Cold Spring Harb Symp Quant Biol,
January 1, 1996;
61(0):
295 - 302.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Takahashi, L. Pinto, and M. Vitaterna
Forward and reverse genetic approaches to behavior in the mouse
Science,
June 17, 1994;
264(5166):
1724 - 1733.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Vitaterna, D. King, A. Chang, J. Kornhauser, P. Lowrey, J. McDonald, W. Dove, L. Pinto, F. Turek, and J. Takahashi
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior
Science,
April 29, 1994;
264(5159):
719 - 725.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. Puchalski and G. R. Lynch
Relationship between Phase Resetting and the Free-Running Period in Djungarian Hamsters
J Biol Rhythms,
April 1, 1992;
7(1):
75 - 83.
[Abstract]
[PDF]
|
|
|
|
