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Journal of Neuroscience, Vol 10, 3707-3713, Copyright © 1990 by Society for Neuroscience
Discrimination learning alters the distribution of protein kinase C in the hippocampus of rats
JL Olds, S Golski, DL McPhie, D Olton, M Mishkin and DL Alkon
Section on Neural Systems, NINDS, National Institutes of Health, Bethesda, Maryland 20892.
Protein kinase C (PKC), an enzyme that plays an essential role in
eukaryotic cell regulation (Nishizuka, 1988; Huang et al., 1989), is
critical to memory storage processes both in the marine snail Hermissenda
crassicornis and in the rabbit (Alkon et al., 1988; Bank et al., 1988; Olds
et al., 1989). Specifically, activation of PKC mimics neurobiological
correlates of classical conditioning in both Hermissenda and the rabbit,
and the distribution of the enzyme within the rabbit hippocampus changes
after Pavlovian conditioning. Here, we report that the amount of PKC, as
assayed by specific binding of 3H- phorbol-12,13-dibutyrate (3H-PDBU),
decreased significantly within the hippocampal CA3 cell region in rats
trained to solve a water maze task either by cognitive mapping or by visual
discrimination strategies, but not in control rats. Furthermore,
hippocampal lesions interfered with acquisition of both of these tasks. We
interpret these findings to support the conclusion that distributional
changes of PKC within the mammalian hippocampus play a crucial role in
memory storage processes.
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