 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 10, 403-401, Copyright © 1990 by Society for Neuroscience
Postmetamorphic cell death in the nervous and muscular systems of Drosophila melanogaster
KI Kimura and JW Truman
Department of Zoology, University of Washington, Seattle 98195.
Programmed cell death occurs in the nervous and muscular system of newly
emerged adult Drosophila melanogaster. Many of the abdominal muscles that
were used for eclosion and wing-spreading behavior degenerate by 12 hr
after eclosion. Related neurons in the ventral ganglion also die within the
first 24 hr. Ligation experiments showed that the muscle breakdown is
triggered by a signal from the anterior region, presumably the head, that
occurs about 1 hr before adult emergence. The timing of this signal
suggests that eclosion hormone may be involved. Although muscle death is
triggered prior to ecdysis, it can be delayed, at least temporarily, by
forcing the emerging flies to show a prolonged ecdysis behavior. In
contrast to the muscles, the death of the neurons is triggered after
emergence. The signal for neuronal degeneration is closely correlated with
the initiation of wing inflation behavior. Ligation and digging experiments
and behavioral manipulations that either blocked or delayed wing expansion
behavior had a parallel effect in suppressing or delaying neuronal death.
This article has been cited by other articles:
|
|
|
|
 
N. C. Peabody, J. B. Pohl, F. Diao, A. P. Vreede, D. J. Sandstrom, H. Wang, P. K. Zelensky, and B. H. White
Characterization of the Decision Network for Wing Expansion in Drosophila Using Targeted Expression of the TRPM8 Channel
J. Neurosci.,
March 18, 2009;
29(11):
3343 - 3353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Galindo, W.-J. Lu, J. H. Park, and J. M. Abrams
The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death
Development,
January 15, 2009;
136(2):
275 - 283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Peabody, F. Diao, H. Luan, H. Wang, E. M. Dewey, H.-W. Honegger, and B. H. White
Bursicon Functions within the Drosophila CNS to Modulate Wing Expansion Behavior, Hormone Secretion, and Cell Death
J. Neurosci.,
December 31, 2008;
28(53):
14379 - 14391.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Hari, M. Deshpande, N. Sharma, N. Rajadhyaksha, N. Ramkumar, K.-i. Kimura, V. Rodrigues, and S. Tole
Chip Is Required for Posteclosion Behavior in Drosophila
J. Neurosci.,
September 10, 2008;
28(37):
9145 - 9150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L. McNabb and J. W. Truman
Light and peptidergic eclosion hormone neurons stimulate a rapid eclosion response that masks circadian emergence in Drosophila
J. Exp. Biol.,
July 15, 2008;
211(14):
2263 - 2274.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Frasch
A matter of timing: microRNA-controlled temporal identities in worms and flies
Genes & Dev.,
June 15, 2008;
22(12):
1572 - 1576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. Sokol, P. Xu, Y.-N. Jan, and V. Ambros
Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
Genes & Dev.,
June 15, 2008;
22(12):
1591 - 1596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Morton, J. A. Stewart, K. K. Langlais, R. A. Clemens-Grisham, and A. Vermehren
Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc-89Da and Gyc-89Db, is necessary for the successful completion of larval and adult ecdysis
J. Exp. Biol.,
May 15, 2008;
211(10):
1645 - 1656.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Davis, S. L. O'Keefe, D. A. Primrose, and R. B. Hodgetts
A neuropeptide hormone cascade controls the precise onset of post-eclosion cuticular tanning in Drosophila melanogaster
Development,
December 15, 2007;
134(24):
4395 - 4404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Duch and T. Mentel
Activity Affects Dendritic Shape and Synapse Elimination during Steroid Controlled Dendritic Retraction in Manduca sexta
J. Neurosci.,
November 3, 2004;
24(44):
9826 - 9837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-i. Kimura, A. Kodama, Y. Hayasaka, and T. Ohta
Activation of the cAMP/PKA signaling pathway is required for post-ecdysial cell death in wing epidermal cells of Drosophila melanogaster
Development,
April 1, 2004;
131(7):
1597 - 1606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Park, A. J. Schroeder, C. Helfrich-Forster, F. R. Jackson, and J. Ewer
Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior
Development,
June 15, 2003;
130(12):
2645 - 2656.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Baker and J. W. Truman
Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program
J. Exp. Biol.,
September 1, 2002;
205(17):
2555 - 2565.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gorski and M. Marra
Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila
Physiol Genomics,
May 10, 2002;
9(2):
59 - 69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Nakano, K. Fujitani, J. Kurihara, J. Ragan, K. Usui-Aoki, L. Shimoda, T. Lukacsovich, K. Suzuki, M. Sezaki, Y. Sano, et al.
Mutations in the Novel Membrane Protein Spinster Interfere with Programmed Cell Death and Cause Neural Degeneration in Drosophila melanogaster
Mol. Cell. Biol.,
June 1, 2001;
21(11):
3775 - 3788.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Bantignies, R. H. Goodman, and S. M. Smolik
Functional Interaction between the Coactivator Drosophila CREB-Binding Protein and ASH1, a Member of the Trithorax Group of Chromatin Modifiers
Mol. Cell. Biol.,
December 15, 2000;
20(24):
9317 - 9330.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. Baker, S. McNabb, and J. Truman
The hormonal coordination of behavior and physiology at adult ecdysis in Drosophila melanogaster
J. Exp. Biol.,
January 11, 1999;
202(21):
3037 - 3048.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Farrell and H Keshishian
Laser ablation of persistent twist cells in Drosophila: muscle precursor fate is not segmentally restricted
Development,
January 1, 1999;
126(2):
273 - 280.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. Yaginuma, M. Tomita, N. Takashita, S. E. McKay, C. Cardwell, Q.-W. Yin, and R. W. Oppenheim
A Novel Type of Programmed Neuronal Death in the Cervical Spinal Cord of the Chick Embryo
J. Neurosci.,
June 1, 1996;
16(11):
3685 - 3703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M E Grether, J M Abrams, J Agapite, K White, and H Steller
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
Genes & Dev.,
July 15, 1995;
9(14):
1694 - 1708.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K White, M. Grether, J. Abrams, L Young, K Farrell, and H Steller
Genetic control of programmed cell death in Drosophila
Science,
April 29, 1994;
264(5159):
677 - 683.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Robinow, W. S. Talbot, D. S. Hogness, and J. W. Truman
Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform
Development,
December 1, 1993;
119(4):
1251 - 1259.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Bargmann and H. Horvitz
Control of larval development by chemosensory neurons in Caenorhabditis elegans
Science,
March 8, 1991;
251(4998):
1243 - 1246.
[Abstract]
[PDF]
|
|
|
|
|
