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Journal of Neuroscience, Vol 10, 412-419, Copyright © 1990 by Society for Neuroscience

ARTICLE

Cardioactive neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and novel related peptides are encoded in multiple copies by a single gene in the snail Lymnaea stagnalis

A Linacre, E Kellett, S Saunders, K Bright, PR Benjamin and JF Burke
Department of Biochemistry, School of Biological Sciences, Brighton, East Sussex, United Kingdom.

The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) is a potent cardioactive neuropeptide in Lymnaea stagnalis. Isolation and sequencing of 2 cDNAs and a genomic clone shows that a single gene encodes a precursor protein which contains 9 copies of the FMRFamide peptide, 2 copies of the related peptide Phe-Leu-Arg-Phe-NH2 (FLRFamide), and single copies of the putative pentapeptides Gln-Phe- Tyr-Arg-lle-NH2 (posttranslationally modified to pQFYRlamide) and Glu- Phe-Leu-Arg-lle-NH2 (EFLRlamide). The gene is transcribed in the CNS and gives rise to a single RNA of 1.7 kb in size. The organization of the Lymnaea gene is significant with respect to the evolution of FMRFamide and related peptides in other organisms.

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