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Journal of Neuroscience, Vol 10, 436-447, Copyright © 1990 by Society for Neuroscience
Head-direction cells recorded from the postsubiculum in freely moving rats. II. Effects of environmental manipulations
JS Taube, RU Muller and JB Ranck Jr
Department of Physiology, SUNY Health Sciences Center, Brooklyn 11203.
The discharge characteristics of postsubicular head-direction cells in a
fixed environment were described in the previous paper (Taube et al.,
1990). This paper reports changes in the firing properties of head-
direction cells following changes in the animal's environment. Head-
direction cells were recorded from rats as they moved freely in a 76-cm-
diameter gray cylinder. A white card, occupying 100 degrees of arc, was
taped to the inside wall of the cylinder and served as the major orienting
spatial cue in the animal's environment. Rotation of the cue card produced
near-equal rotation in the preferred firing direction of head-direction
cells, with minimal changes in peak firing rate, directional firing range,
or asymmetry of the firing-rate/head- direction function. Card removal had
no effect on peak firing rate or range of firing, but in 8/13 cells the
preferred direction rotated by at least 24 degrees. Similarly, changing the
shape of the environment to a rectangular or square enclosure caused the
preferred firing direction to rotate by at least 48 degrees for 8/10 cells
in the rectangle and 3/8 cells in the square, with minimal changes in the
peak firing rate or directional firing range. Hand holding the animals and
moving them around the cylinder had no effect on the preferred direction or
firing range of the cell, but decreased the maximal firing rate in 7/9
cells. On 2 occasions, 2 head-direction cells were recorded simultaneously.
The rotation of the preferred firing direction for one cell was the same as
the rotation of the preferred direction for the second cell after each
environmental manipulation. These results demonstrate that specific visual
cues in the environment can exert control over the preferred firing
direction and indicate that head- direction cell firing is not a simple
sensory response to visual cues, but rather represents more abstract
information concerning the animal's spatial relationship with its
environment. The constancy of the angle between the preferred firing
directions of pairs of simultaneously recorded head-direction cells
suggests that there is a fixed mapping of the population onto direction
within the environment. Thus, environmental manipulations appear to cause
only a change in the reference direction, but leave all other discharge
characteristics of directional cells unchanged. In the discussion,
comparisons are drawn between the responses of head-direction cells and
hippocampal place cells to similar environmental manipulations (Muller and
Kubie, 1987), and ways in which these 2 spatial systems interact in
navigation are discussed.(ABSTRACT TRUNCATED AT 400 WORDS)
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