 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 10, 558-570, Copyright © 1990 by Society for Neuroscience
Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II
B Knusel, PP Michel, JS Schwaber and F Hefti
Department of Biological Sciences, University of Southern California, Los Angeles 90089.
To study the selectivity of neurotrophic actions in the brain, we analyzed
the actions of several known growth factors on septal cholinergic, pontine
cholinergic, and mesencephalic dopaminergic neurons in culture. Similar to
nerve growth factor (NGF), basic fibroblast growth factor (bFGF) stimulated
choline acetyltransferase activity in septal cultures. In contrast to NGF,
bFGF also enhanced dopamine uptake in mesencephalic cultures and stimulated
cell proliferation in all 3 culture types. Insulin and the insulin-like
growth factors I and II stimulated transmitter-specific differentiation and
cell proliferation in all culture types. Epidermal growth factor (EGF)
produced a small increase in dopamine uptake by mesencephalic cells and
stimulated cell proliferation in all culture types. In septal cultures,
bFGF was most effective when given at early culture times, NGF at later
times. The stimulatory actions of bFGF and insulin did not require the
presence of glial cells and were not mediated by NGF. In mesencephalic
cultures, the stimulation of dopamine uptake by bFGF and EGF was dependent
on glial proliferation. The results suggest different degrees of
selectivity of the neurotrophic molecules. NGF and, very similarly, bFGF
seem to influence septal cholinergic neurons directly and rather
selectively, whereas the neurotrophic actions of insulin and the
insulin-like growth factors appear to be more general.
This article has been cited by other articles:
|
|
|
|
 
M. Timmer, K. Cesnulevicius, C. Winkler, J. Kolb, E. Lipokatic-Takacs, J. Jungnickel, and C. Grothe
Fibroblast Growth Factor (FGF)-2 and FGF Receptor 3 Are Required for the Development of the Substantia Nigra, and FGF-2 Plays a Crucial Role for the Rescue of Dopaminergic Neurons after 6-Hydroxydopamine Lesion
J. Neurosci.,
January 17, 2007;
27(3):
459 - 471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Cesnulevicius, M. Timmer, M. Wesemann, T. Thomas, T. Barkhausen, and C. Grothe
Nucleofection Is the Most Efficient Nonviral Transfection Method for Neuronal Stem Cells Derived from Ventral Mesencephali with No Changes in Cell Composition or Dopaminergic Fate
Stem Cells,
December 1, 2006;
24(12):
2776 - 2791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Murase and R. D. McKay
A specific survival response in dopamine neurons at most risk in Parkinson's disease.
J. Neurosci.,
September 20, 2006;
26(38):
9750 - 9760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Dai, L. D. Lercher, P. M. Clinton, Y. Du, D. L. Livingston, C. Vieira, L. Yang, M. M. Shen, and C. F. Dreyfus
The Trophic Role of Oligodendrocytes in the Basal Forebrain
J. Neurosci.,
July 2, 2003;
23(13):
5846 - 5853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Smith and V. D. Ramirez
DARP-36aa Selectively Promotes Survival and Morphological Development of Cultured Mesencephalic Neurons
J. Neurosci.,
January 1, 2003;
23(1):
252 - 259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Korada, W. Zheng, C. Basilico, M. L. Schwartz, and F. M. Vaccarino
Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex
J. Neurosci.,
February 1, 2002;
22(3):
863 - 875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Sone, B. K. Deo, and A. K. Kumagai
Enhancement of Glucose Transport by Vascular Endothelial Growth Factor in Retinal Endothelial Cells
Invest. Ophthalmol. Vis. Sci.,
June 1, 2000;
41(7):
1876 - 1884.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. M. Daadi and S. Weiss
Generation of Tyrosine Hydroxylase-Producing Neurons from Precursors of the Embryonic and Adult Forebrain
J. Neurosci.,
June 1, 1999;
19(11):
4484 - 4497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Walter, M. Berry, D. J. Hill, S. Cwyfan-Hughes, J. M. P. Holly, and A. Logan
Distinct Sites of Insulin-Like Growth Factor (IGF)-II Expression and Localization in Lesioned Rat Brain: Possible Roles of IGF Binding Proteins (IGFBPs) in the Mediation of IGF-II Activity
Endocrinology,
January 1, 1999;
140(1):
520 - 532.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Arsenijevic and S. Weiss
Insulin-Like Growth Factor-I Is a Differentiation Factor for Postmitotic CNS Stem Cell-Derived Neuronal Precursors: Distinct Actions from Those of Brain-Derived Neurotrophic Factor
J. Neurosci.,
March 15, 1998;
18(6):
2118 - 2128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gonzalo and M. E. Linder
SNAP-25 Palmitoylation and Plasma Membrane Targeting Require a Functional Secretory Pathway
Mol. Biol. Cell,
March 1, 1998;
9(3):
585 - 597.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Kar, D. Seto, S. Dore, U.-K. Hanisch, and R. Quirion
Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation
PNAS,
December 9, 1997;
94(25):
14054 - 14059.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schwab, M. Spranger, S. Krempien, W. Hacke, and M. Bettendorf
Plasma Insulin-like Growth Factor I and IGF Binding Protein 3 Levels in Patients With Acute Cerebral Ischemic Injury
Stroke,
September 1, 1997;
28(9):
1744 - 1748.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. G. Waxman and J. D. Kocsis
Spinal Cord Repair: Progress Towards a Daunting Goal
Neuroscientist,
July 1, 1997;
3(4):
263 - 269.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Nonner, E. F. Barrett, and J. N. Barrett
Neurotrophin Effects on Survival and Expression of Cholinergic Properties in Cultured Rat Septal Neurons under Normal and Stress Conditions
J. Neurosci.,
November 1, 1996;
16(21):
6665 - 6675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. S. Treanor, C. Schmelzer, B. Knusel, J. W. Winslow, D. L. Shelton, F. Hefti, K. Nikolics, and L. E. Burton
Heterodimeric Neurotrophins Induce Phosphorylation of Trk Receptors and Promote Neuronal Differentiation in PC12 Cells
J. Biol. Chem.,
September 29, 1995;
270(39):
23104 - 23110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lin, D. Doherty, J. Lile, S Bektesh, and F Collins
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
Science,
May 21, 1993;
260(5111):
1130 - 1132.
[Abstract]
[PDF]
|
|
|
|
