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Journal of Neuroscience, Vol 10, 764-784, Copyright © 1990 by Society for Neuroscience
Differential expression of two neuronal intermediate-filament proteins, peripherin and the low-molecular-mass neurofilament protein (NF-L), during the development of the rat
M Escurat, K Djabali, M Gumpel, F Gros and MM Portier
College de France, Biochimie Cellulaire, Paris.
The expression of peripherin, an intermediate filament protein, had been
shown by biochemical methods to be localized in the neurons of the PNS.
Using immunohistochemical methods, we analyzed this expression more
extensively during the development of the rat and compared it with that of
the low-molecular-mass neurofilament protein (NF-L), which is expressed in
every neuron of the CNS and PNS. The immunoreactivity of NF-L is first
apparent at the 25-somite stage (about 11 d) in the ventral horn of the
spinal medulla and in the posterior part of the rhombencephalon. The
immunoreactivity of peripherin appears subsequently, first colocalized with
that of NF-L. Both immunoreactivities then spread out along rostral and
caudal directions, but whereas the immunoreactivity of NF-L finally becomes
noticeable in every part of the nervous system, that of peripherin remains
localized to (1) the motoneurons of the ventral horn of the spinal medulla;
(2) the autonomic ganglionic and preganglionic neurons; and (3) the sensory
neurons. These results demonstrate that, in the neurons that originate from
migrating neural crest cells, the immunoreactivities of peripherin and of
NF-L become apparent only when they have reached their destination. The
results also show that peripherin is expressed more widely than has been
previously observed and that this protein occurs in neuronal populations
from different lineages (neural tube, neural crest, placodes) with
different functions (motoneurons, sensory and autonomic neurons). The
common point of these neurons is that they all have axons lying, at least
partly, at the outside of the axis constituted by the encephalon and the
spinal medulla; this suggests that peripherin might play a role in the
recognition of the axonal pathway through the intermediary of membrane
proteins.
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