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Journal of Neuroscience, Vol 10, 826-836, Copyright © 1990 by Society for Neuroscience
The time course and amplitude of EPSPs evoked at synapses between pairs of CA3/CA1 neurons in the hippocampal slice
RJ Sayer, MJ Friedlander and SJ Redman
John Curtin School of Medical Research, Australian National University, Canberra, AC.T.
Unitary EPSPs were evoked in CA1 pyramidal neurons by activation of single
CA3 pyramidal neurons. Seventy-one EPSPs were recorded. The peak amplitudes
of these EPSPs ranged from 30 to 665 microV with a mean of 131 microV. Rise
times and half-widths were measured, the means +/- SD being 3.9 +/- 1.8 and
19.5 +/- 8.0 msec, respectively. The time courses of these EPSPs were
consistent with a brief synaptic current at a localized electrotonic region
of the dendritic tree followed by passive spread of current to the soma.
EPSPs varied in amplitude from trial to trial. Sufficient records were
collected for 12 EPSPs to demonstrate that this variation was greater than
could be accounted for by baseline noise. The amplitude variations of one
EPSP were reliably resolved from the background noise, and this EPSP
fluctuated between 4 discrete amplitudes (including failures) separated by
a quantal increment of 278 microV.
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