Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist

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Journal of Neuroscience, Vol 10, 909-925, Copyright © 1990 by Society for Neuroscience

ARTICLE

Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist

MF Bear, A Kleinschmidt, QA Gu and W Singer
Max Planck Institut fur Hirnforschung, Frankfurt, Federal Republic of Germany.
To assess the possibility that NMDA receptors play a special role in visual cortical plasticity, the selective antagonist 2-amino-5- phosphonovaleric acid (APV) was continuously infused into the striate cortex of kittens as the visual environment was manipulated during the critical period. The cortex was studied using single-unit recording from sites between 3 and 6 mm from the infusion cannulae. One week of D,L-APV infusion coincident with monocular deprivation or "reverse suture" produced a concentration-dependent increase in the percentage of neurons that (1) lacked normal orientation selectivity and (2) were responsive to stimulation of the deprived eye. These effects outlasted the presence of the drug in the tissue. APV treatment also prevented the acquisition of selectivity and visual responsiveness that normally results from monocular visual experience after dark-rearing. Lasting effects of chronic APV infusion were not observed in adult striate cortex. The effects of APV on kitten striate cortex depended on the presence of the D stereoisomer as infusion of L-APV was without effect. Estimates of extracellular concentration using 3H-APV indicated that significant effects could be obtained with concentrations as low as 20 microM D,L-APV. Recordings from units during infusion indicated that visual responses were reduced by APV. Nonetheless, a normal percentage of visually responsive neurons was found at sites greater than or equal to 3 mm from the infusion cannula. There was no evidence that chronic APV infusion affected the sampling frequency of recorded neurons or disrupted cytoarchitecture at the sites further than 3 mm from the infusion cannula. Taken together, the data indicate that the effects of APV on kitten striate cortex are likely due specifically to the blockade of NMDA receptors. These data are considered in relation to several hypotheses concerning the role of NMDA receptors in the experience-dependent development of striate cortex.

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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J. Neurosci., October 15, 1997; 17(20): 7967 - 7973.
[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

J. A. Gordon
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J. Shi, S. M. Aamodt, and M. Constantine-Paton
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J. Neurosci., August 15, 1997; 17(16): 6264 - 6276.
[Abstract] [Full Text] [PDF]

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J Neurophysiol, August 1, 1997; 78(2): 1096 - 1107.
[Abstract] [Full Text] [PDF]

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NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex
J. Neurosci., April 1, 1997; 17(7): 2469 - 2476.
[Abstract] [Full Text] [PDF]

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J. Neurosci., March 15, 1997; 17(6): 2040 - 2055.
[Abstract] [Full Text] [PDF]

K. S. Cramer, A. Angelucci, J.-O. Hahm, M. B. Bogdanov, and M. Sur
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[Abstract] [Full Text] [PDF]

L. C. Katz and C. J. Shatz
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Science, November 15, 1996; 274(5290): 1133 - 1138.
[Abstract] [Full Text]

A. N. Moore, M. N. Waxham, and P. K. Dash
Neuronal Activity Increases the Phosphorylation of the Transcription Factor cAMP Response Element-binding Protein (CREB) in Rat Hippocampus and Cortex
J. Biol. Chem., June 14, 1996; 271(24): 14214 - 14220.
[Abstract] [Full Text] [PDF]

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W. Singer
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H. Thoenen
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Science, October 27, 1995; 270(5236): 593 - 598.
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P. Montague, C. Gancayco, M. Winn, R. Marchase, and M. Friedlander
Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex
Science, February 18, 1994; 263(5149): 973 - 977.
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R. Kalb
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Development, January 11, 1994; 120(11): 3063 - 3071.
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P R Montague and T J Sejnowski
The predictive brain: temporal coincidence and temporal order in synaptic learning mechanisms.
Learn. Mem., January 1, 1994; 1(1): 1 - 33.
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S Rabacchi, Y Bailly, N Delhaye-Bouchaud, and J Mariani
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Science, June 26, 1992; 256(5065): 1823 - 1825.
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A Ghosh and C. Shatz
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Science, March 13, 1992; 255(5050): 1441 - 1443.
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R. Kalb and S Hockfield
Induction of a neuronal proteoglycan by the NMDA receptor in the developing spinal cord
Science, October 12, 1990; 250(4978): 294 - 296.
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R.G.M. Morris
Toward a Representational Hypothesis of the Role of Hippocampal Synaptic Plasticity in Spatial and Other Forms of Learning
Cold Spring Harb Symp Quant Biol, January 1, 1990; 55(0): 161 - 173.
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M. Constantine-Paton
NMDA Receptor as a Mediator of Activity-dependent Synaptogenesis in the Developing Brain
Cold Spring Harb Symp Quant Biol, January 1, 1990; 55(0): 431 - 443.
[Abstract] [PDF]

S. Hockfield, R.G. Kalb, S. Zaremba, and H. Fryer
Expression of Neural Proteoglycans Correlates with the Acquisition of Mature Neuronal Properties in the Mammalian Brain
Cold Spring Harb Symp Quant Biol, January 1, 1990; 55(0): 505 - 514.
[Abstract] [PDF]