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Journal of Neuroscience, Vol 10, 947-951, Copyright © 1990 by Society for Neuroscience
T-type calcium channels: heterogeneous expression in rat sensory neurons and selective modulation by phorbol esters
JE Schroeder, PS Fischbach and EW McCleskey
Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri 63110.
We report selective inhibition of low-threshold, T-type calcium channels by
a phorbol ester in rat sensory neurons. Cells were exposed, either acutely
or with 15-60 min preincubations, to low concentrations of phorbol
12-myristate 13-acetate, (PMA), an activator of protein kinase C; if the
temperature was 29 degrees C or higher, T-type Ca current was diminished
without effect on high-threshold Ca current. In untreated cells, the
amplitude of T-type Ca current varies widely among neighboring sensory
neurons. T channels are absent in about 25% of cells, provide a small
current near threshold for the majority of cells, and are a dominant
pathway for calcium entry in a small subset of neurons. The results are of
interest because, by selectively inhibiting a calcium channel expressed
differently among subpopulations of sensory neurons, activation of protein
kinase C might selectively suppress particular sensations.
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