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Journal of Neuroscience, Vol 10, 1062-1069, Copyright © 1990 by Society for Neuroscience
The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning
JE LeDoux, P Cicchetti, A Xagoraris and LM Romanski
Center for Neural Science, New York University, New York 10003.
Previous work has implicated projections from the acoustic thalamus to the
amygdala in the classical conditioning of emotional responses to auditory
stimuli. The purpose of the present studies was to determine whether the
lateral amygdaloid nucleus (AL), which is a major subcortical target of
projections from the acoustic thalamus, might be the sensory interface of
the amygdala in emotional conditioning. Lesions were placed in AL of rats
and the effects on emotional conditioning were examined. Lesions of AL, but
not lesions of the striatum above or the cortex adjacent to the AL,
interfered with emotional conditioning. Lesions that only partially
destroyed AL or lesions placed too ventrally that completely missed AL had
no effect. AL lesions did not affect the responses elicited following
nonassociative (random) training. AL is thus an essential link in the
circuitry through which auditory stimuli are endowed with affective
properties and may function as the sensory interface of the amygdala during
emotional learning.
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