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Journal of Neuroscience, Vol 10, 1091-1098, Copyright © 1990 by Society for Neuroscience
Serotonin immunoreactive boutons make synapses with feline phrenic motoneurons
PM Pilowsky, D de Castro, I Llewellyn-Smith, J Lipski and MD Voss
Department of Physiology, School of Medicine, University of Auckland, New Zealand.
In anesthetized cats, phrenic motoneurons were intracellularly labeled with
HRP. Immunohistochemistry was used to localize serotonin-like
immunoreactivity that was present in numerous boutons and nerve fibers
within the ventral horn of the C5 spinal segment. Immunoreactive boutons
were frequently found in apposition to phrenic motoneurons, but these close
contacts were more common on the dendrites than the cell body. At the
electron microscope level, serotonin-immunoreactive boutons were found to
make synapses with well-defined postsynaptic densities on proximal and
distal dendrites of phrenic motoneurons. These results suggest that
serotonin-containing neurons may directly affect the excitability of
phrenic motoneurons, mainly through an input onto their extensive dendritic
trees.
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