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Journal of Neuroscience, Vol 10, 1331-1340, Copyright © 1990 by Society for Neuroscience
Regulation of cytochrome oxidase protein levels by functional activity in the macaque monkey visual system
RF Hevner and MT Wong-Riley
Department of Anatomy and Cellular Biology, Medical College of Wisconsin, Milwaukee 53226.
The activity of cytochrome oxidase (CO), a mitochondrial enzyme of
oxidative energy metabolism, is regulated by nerve cell functional
activity. The mechanism of CO activity regulation was studied using
histochemical and immunohistochemical methods to show the distributions of
CO activity and protein, respectively, in the macaque monkey visual system
under normal and experimental conditions. In normal animals, patterns of CO
activity were found to reflect underlying patterns of CO protein
distribution; for example, puffs of high CO activity in cortical area 17
contained high levels of CO protein. Experimental animals were injected
monocularly with TTX for 3-4 weeks; this treatment blocks retinal impulses
in the injected eye and results in decreased CO activity in lateral
geniculate laminae and striate cortical columns normally driven by the
treated eye. The experimentally induced decreases in CO activity were also
found to reflect underlying parallel decreases in CO protein levels. These
results suggest that CO activity is regulated mainly at the level of the
local amount rather than the turnover number of the enzyme and imply that
the rates of CO synthesis and/or degradation are regulated by neural
functional activity.
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