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Journal of Neuroscience, Vol 10, 1380-1387, Copyright © 1990 by Society for Neuroscience
Distinct patterns of expression of two VAMP genes within the rat brain
WS Trimble, TS Gray, LA Elferink, MC Wilson and RH Scheller
Department of Biological Sciences, Stanford University, California 94305.
VAMPs are synaptic vesicle-specific proteins composed of a carboxy-
terminal hydrophobic membrane anchor and an approximately 100 amino acid
domain oriented towards the cytoplasm. In rat, two 77% homologous VAMP
genes are expressed in the CNS. To precisely localize the neurons
expressing these 2 forms of VAMP, we have used RNA blotting and in situ
hybridization histochemistry with RNA probes specific for the 3'
untranslated regions of the transcripts. These experiments revealed that
the 2 genes are expressed in distict, but slightly overlapping, patterns in
the rat brain. VAMP-1 expression is localized to a limited number of
nuclei, particularly those involved in modulating somatomotor functions,
while VAMP-2 expression is more ubiquitous, being found in nuclei
associated with autonomic, sensory, and integrative roles. These data
suggest that the specific structural features of individual VAMPs may play
an important role in synaptic vesicle metabolism.
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