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Journal of Neuroscience, Vol 10, 1407-1414, Copyright © 1990 by Society for Neuroscience
Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. I. Establishment of cell classes
A Larkman and A Mason
University Laboratory of Physiology, Oxford, England.
The purpose of this study was to determine whether different classes of
neocortical pyramidal neurons possess distinctive electrophysiological
properties. Neurons were assigned to classes on the basis of their
somadendritic morphology as revealed by intracellular HRP injection. The
electrophysiological features of each class are compared in the following
paper (Mason and Larkman, 1990). Coronal slices were prepared from the
visual cortex of the albino rat and maintained in vitro. Pyramidal neurons
from layers 2/3 and 5 were impaled with electrodes containing HRP. After
intracellular recording, the cells were injected, reacted to visualize the
enzyme, and examined in the light microscope. The 18 neurons from layer 2/3
showed an underlying similarity of somadendritic morphology and were
considered to constitute a single cell class, although some features varied
with the depth of the soma in the cortex. The 22 layer 5 cells were more
diverse and were divided into 2 main classes. Eleven cells had single,
thick apical trunks which ascended to close to the layer 1 border then
branched to form a terminal arbor. These cells were termed thick layer 5
cells, and were found mainly in the upper part of the layer. Ten layer 5
cells had single apical trunks which tapered to a fine diameter and
terminated, without forming an obvious terminal arbor, near the top of
layer 4 (3 cells) or in layer 2/3 (7 cells). These cells were termed
slender layer 5 cells and were found throughout the layer.(ABSTRACT
TRUNCATED AT 250 WORDS)
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