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Journal of Neuroscience, Vol 10, 1415-1428, Copyright © 1990 by Society for Neuroscience
Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. II. Electrophysiology
A Mason and A Larkman
University Laboratory of Physiology, Oxford, England.
The aim of this study was to determine whether the different morphological
classes of pyramidal neurons in layers 2/3 and 5 of rat visual cortex
(Larkman and Mason, 1990) have particular electrophysiological properties.
Neurons in in vitro slices of rat visual cortex were impaled with glass
micropipettes containing horseradish peroxidase (HRP) and studied using
current-clamp techniques prior to pressure injection of HRP into the
neurons. On morphological grounds, cells stained in layer 2/3 were placed
into a single class whereas layer 5 cells were divided into 2 classes.
Cells in one of these classes had thick apical dendrites which arborized in
layer 1, whereas the apical dendrites of cells in the other class were
thinner and did not reach layer 1 (Larkman and Mason, 1990). Despite
variation between individual cells of a single class, significant
differences were found in the time constants, current/voltage relations,
and repetitive firing behaviors of the 3 classes. Burst firing responses to
injected current pulses were confined to the layer 5 cells with thick
apical dendrites. These results add to those from other areas of the brain
demonstrating that the electrophysiological properties of pyramidal neurons
are heterogeneous. Furthermore, we have shown that distinctive intrinsic
membrane properties of pyramidal neurons in visual cortex are correlated
with different morphologies.
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