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Journal of Neuroscience, Vol 10, 2008-2017, Copyright © 1990 by Society for Neuroscience
The firing of hippocampal place cells in the dark depends on the rat's recent experience
GJ Quirk, RU Muller and JL Kubie
Department of Physiology, State University of New York, Brooklyn 11203.
Hippocampal "place cells" fire when a freely moving rat is in a given
location. The firing of these cells is controlled by visual and nonvisual
environmental cues. The effects of darkness on the firing of place cells
was studied using the task of Muller et al. (1987), in which rats were
trained to chase randomly scattered food pellets in a cylindrical drum with
a white cue-card attached to the wall. The position of the rats was tracked
via an infrared LED on the headstage with a video system linked to
computer. Two experimental protocols were used: in the first, lights were
turned off after the rat had already been placed in the chamber; in the
second, the rat was placed in the darkened chamber. The dark segments
produced by these 2 methods were identical with respect to light and other
cues but differed with respect to the rat's experience. The firing patterns
of 24 of 28 cells were unaffected by darkness when it was preceded by a
light period. In contrast, the firing patterns of 14 of 22 cells changed
dramatically when the rats were put into the darkened chamber. Furthermore,
the majority of cells that changed their firing pattern in initial darkness
maintained that change when the lights were turned on. These results show
that place cells can fire differently in identical cue situations and that
the best predictor of firing pattern is a combination of current cues and
the rat's recent experience. The results are discussed in terms of mnemonic
properties of hippocampal cells and "remapping" of place cell
representations.
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