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Journal of Neuroscience, Vol 10, 2412-2419, Copyright © 1990 by Society for Neuroscience
Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse
KG Ruit, PA Osborne, RE Schmidt, EM Johnson Jr and WD Snider
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110.
We have investigated the effects of prolonged systemic injections of nerve
growth factor (NGF) and its antiserum on the survival and morphology of
sympathetic ganglion cells in adult mice. Using intracellular injections of
Lucifer yellow in lightly fixed superior cervical ganglia, we show that
total dendritic lengths of ganglion cells are increased 29% after 2 weeks
of NGF treatment. The increased dendritic length is characterized by
increased branching within the dendritic arborization and not by the
addition of new primary dendrites. In addition, cell soma cross-sectional
area was increased 45%. Conversely, administration of NGF antiserum for 1
month decreased total dendritic length by 33%, decreased ganglion cell body
size by 26%, and reduced the number of neurons in the ganglion by 25%.
After 3 months of NGF antiserum treatment, the number of neurons in the
ganglion was reduced a total of 41%. NGF antiserum treatment for 1 month in
aged (22 months old) animals reduced ganglion cell body size by 21% and
cell number by 22%, decreases that are comparable to those observed in
young adult animals. Our results indicate that, even in maturity,
sympathetic ganglion cells remain dependent on NGF for survival and
maintenance of dendritic geometry, and this dependence continues into old
age.
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