QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yip, J. W. Search for Related Content PubMed PubMed Citation Articles by Yip, J. W.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 10, 2476-2484, Copyright © 1990 by Society for Neuroscience

ARTICLE

Identification of location and timing of guidance cues in sympathetic preganglionic axons of the chick

JW Yip
Department of Physiology, School of Medicine, University of Pittsburgh, Pennsylvania 15261.

The outgrowth of preganglionic axons into the sympathetic trunk of the chick occurs at stages 26-27 (5-5 1/2 d), beginning with C16 and T1 and followed by progressively more caudal spinal cord segments. The direction of preganglionic projections is segment specific, with T1 preganglionic neurons projecting predominantly in the rostral direction and T4 preganglionic neurons projecting predominantly in the caudal direction. These projections are correct from the outset. A previous study (Yip, 1987) has shown that removal of the neural crest, precursors of target ganglion cells, did not alter the trajectories of preganglionic axons, indicating that target cues are not required for the guidance of these axons. The present work extends that study and examines, through surgical manipulations of the developing embryo, the location and time of appearance of preganglionic axonal guidance cues. Spinal cord transplantation experiments show that segment-specific patterns of preganglionic outgrowth are determined by the local environment of axonal growth and not by the identity of preganglionic populations. In addition, spinal cord transplants of age-mismatched donors and hosts indicate that the timing of preganglionic outgrowth is also under local environmental control. These findings suggest that preganglionic axonal outgrowth is guided by local cues which may appear in a controlled spatiotemporal manner.

This article has been cited by other articles:

				J. W. Yip, Y. P. L. Yip, and C. Capriotti Segmental Specificity of Chick Sympathetic Preganglionic Projections Is Influenced by Preganglionic Neurons from Neighboring Spinal Cord Segments J. Neurosci., December 15, 1998; 18(24): 10473 - 10480. [Abstract] [Full Text] [PDF]

				M. Spence, J Yip, and C. Erickson The dorsal neural tube organizes the dermamyotome and induces axial myocytes in the avian embryo Development, January 1, 1996; 122(1): 231 - 241. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help