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Journal of Neuroscience, Vol 10, 2727-2734, Copyright © 1990 by Society for Neuroscience
Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation
YY Lai and JM Siegel
Veterans Administration Medical Center, Sepulveda, California 91343.
Stimulation of the midbrain retrorubral (RRN), ventral paralemniscal
tegmental field (vFTP), reticular tegmental (TRN), and pedunculopontine
tegmental (PPN) nuclei was found to produce bilateral suppression of muscle
tone in the unanesthetized, decerebrate animal. The RRN is the most rostral
area shown to produce such suppression. This muscle tone suppression was
frequency- and intensity-dependent. At low stimulus intensities, bilateral
suppression was produced at these sites. At higher current and frequency
levels, 2 types of muscle responses were found, excitation in PPN and RRN
and initial suppression followed by excitation in TRN and vFTP. The mean
latency to muscle tone suppression was not significantly different in TRN
(36.8 msec) and RRN (36.5 msec). However, muscle tone suppression latency
was significantly shorter in vFTP (31 msec) and PPN (27.1 msec). In
addition to muscle tone suppression, stepping-like activity could be
elicited at the same points by consecutive train stimulations in PPN and
single train stimulation in TRN and vFTP. Thus, systems producing atonia
are colocalized with those producing locomotion. We hypothesize that the
midbrain atonia regions control more caudal regions producing muscle tone
suppression in REM sleep, and that the locomotor and atonia eliciting
regions are normally coactivated during REM sleep.
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