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Journal of Neuroscience, Vol 10, 2974-2984, Copyright © 1990 by Society for Neuroscience
The differentiation of excitability in embryonic chick limb motoneurons
DP McCobb, PM Best and KG Beam
Department of Physiology, Colorado State University, Fort Collins 80523.
The well-documented role of neuromuscular activity as a regulator of
motoneuron and muscle development raises important questions about the
differentiation of excitability in motoneurons. We have recently described
changes in expression of voltage-dependent calcium currents that take place
during neuromuscular development in the chick embryo (McCobb et al., 1989).
We now report similar analyses, using whole-cell patch-recording methods,
of the major currents underlying action potential generation in the same
motoneurons. Studies were conducted on identified hindlimb motoneurons
isolated from the spinal cord at 3 very different stages of chick hindlimb
development. Motoneurons could generate overshooting action potentials at
the earliest stage studied [embryonic day 4 (E4)]. However, large changes
in densities of several voltage-dependent ionic currents occurred
thereafter. E6 and E11 motoneurons had progressively larger INa densities
and, consequently, greater action potential amplitudes. Densities of 2
potassium currents, Ik and IA, increased on separate schedules. The
relatively late and much larger increase in IA resulted in a substantial
developmental decline in action potential duration. These changes, which
will greatly affect motoneuron output to muscle by affecting Ca2+ entry
through voltage-gated channels, occur at the same time that
activity-dependent developmental changes occur in the neuromuscular system.
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