 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 10, 3135-3147, Copyright © 1990 by Society for Neuroscience
1B1075: a brain- and pituitary-specific mRNA that encodes a novel chromogranin/secretogranin-like component of intracellular vesicles
HP Ottiger, EF Battenberg, AP Tsou, FE Bloom and JG Sutcliffe
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.
The rat 1B1075 mRNA encodes a 533-residue novel
chromogranin/secretogranin-like acidic protein that contains an apparent
secretion signal, several pairs of tandem basic residues, and internally
repeated sequence elements. 1B1075 transcripts are detected, by blotting
and in situ hybridization, at the highest levels in the neocortex,
hippocampus, cerebellar cortex, selected pontine and diencephalic nuclei,
and presumptive pituitary corticotrophs, at lower levels in specific nuclei
in most other brain regions, but in none of several other tissues.
Utilizing antisera to several nonoverlapping synthetic peptide fragments of
the predicted protein sequence, we detect a brain- and pituitary-specific
57-kDa protein in cellular processes and fiber tracts, generally consistent
with axonal transport from the cell bodies identified by in situ
hybridization. Ultrastructural studies demonstrate that this protein is a
component of intraneuronal vesicles in axons and vesicle-like structures in
dendrites. Based on these data, we suggest the name Secretogranin III for
the 1B1075 gene product. In related collaborative studies, a mouse deleted
for the 1B1075-homologous gene has been produced that should allow
assessment of its physiological role.
This article has been cited by other articles:
|
|
|
|
 
S. Paco, E. Pozas, and F. Aguado
Secretogranin III Is an Astrocyte Granin That Is Overexpressed in Reactive Glia
Cereb Cortex,
November 5, 2009;
(2009)
bhp202v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Hotta, M. Hosaka, A. Tanabe, and T. Takeuchi
Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC
J. Endocrinol.,
July 1, 2009;
202(1):
111 - 121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Zhao, A. Basak, A. O. L. Wong, W. Ko, A. Chen, G. C. Lopez, C. L. Grey, L. F. Canosa, G. M. Somoza, J. P. Chang, et al.
The Secretogranin II-Derived Peptide Secretoneurin Stimulates Luteinizing Hormone Secretion from Gonadotrophs
Endocrinology,
May 1, 2009;
150(5):
2273 - 2282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Prasad, A. A. Yanagihara, A. L. Small-Howard, H. Turner, and A. J. Stokes
Secretogranin III Directs Secretory Vesicle Biogenesis in Mast Cells in a Manner Dependent upon Interaction with Chromogranin A
J. Immunol.,
October 1, 2008;
181(7):
5024 - 5034.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Han, M. Suda, K. Tsuzuki, R. Wang, Y. Ohe, H. Hirai, T. Watanabe, T. Takeuchi, and M. Hosaka
A Large Form of Secretogranin III Functions as a Sorting Receptor for Chromogranin A Aggregates in PC12 Cells
Mol. Endocrinol.,
August 1, 2008;
22(8):
1935 - 1949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tanabe, T. Yanagiya, A. Iida, S. Saito, A. Sekine, A. Takahashi, T. Nakamura, T. Tsunoda, S. Kamohara, Y. Nakata, et al.
Functional Single-Nucleotide Polymorphisms in the Secretogranin III (SCG3) Gene that Form Secretory Granules with Appetite-Related Neuropeptides Are Associated with Obesity
J. Clin. Endocrinol. Metab.,
March 1, 2007;
92(3):
1145 - 1154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hosaka, M. Suda, Y. Sakai, T. Izumi, T. Watanabe, and T. Takeuchi
Secretogranin III Binds to Cholesterol in the Secretory Granule Membrane as an Adapter for Chromogranin A
J. Biol. Chem.,
January 30, 2004;
279(5):
3627 - 3634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Taupenot, K. L. Harper, and D. T. O'Connor
The Chromogranin-Secretogranin Family
N. Engl. J. Med.,
March 20, 2003;
348(12):
1134 - 1149.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sakai, M. Hosaka, Y. Hira, T. Harumi, Y. Ohsawa, H. Wang, T. Takeuchi, Y. Uchiyama, and T. Watanabe
Immunocytochemical Localization of Secretogranin III in the Anterior Lobe of Male Rat Pituitary Glands
J. Histochem. Cytochem.,
February 1, 2003;
51(2):
227 - 238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hosaka, T. Watanabe, Y. Sakai, Y. Uchiyama, and T. Takeuchi
Identification of a Chromogranin A Domain That Mediates Binding to Secretogranin III and Targeting to Secretory Granules in Pituitary Cells and Pancreatic beta -Cells
Mol. Biol. Cell,
October 1, 2002;
13(10):
3388 - 3399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Saberan-Djoneidi, R. Picart, D. Escalier, M. Gelman, A. Barret, C. Tougard, J. Glowinski, and M. Levi-Strauss
A 21-kDa Polypeptide Belonging to a New Family of Proteins Is Expressed in the Golgi Apparatus of Neural and Germ Cells
J. Biol. Chem.,
February 13, 1998;
273(7):
3909 - 3914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C.M. Holthuis, E. J.R. Jansen, and G. J.M. Martens
Secretogranin III Is a Sulfated Protein Undergoing Proteolytic Processing in the Regulated Secretory Pathway
J. Biol. Chem.,
July 26, 1996;
271(30):
17755 - 17760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Dél. Sabéran-Djoneidi, I. Marey-Semper, R.ée Picart, J.-M. Studler, C. Tougard, J. Glowinski, and M. Lévi-Strauss
A 19-kDa Protein Belonging to a New Family Is Expressed in the Golgi Apparatus of Neural Cells
J. Biol. Chem.,
January 27, 1995;
270(4):
1888 - 1893.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Holthuis, E. Jansen, M. van Riel, and G. Martens
Molecular probing of the secretory pathway in peptide hormone-producing cells
J. Cell Sci.,
January 10, 1995;
108(10):
3295 - 3305.
[Abstract]
[PDF]
|
|
|
|
|
