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Journal of Neuroscience, Vol 10, 3135-3147, Copyright © 1990 by Society for Neuroscience
1B1075: a brain- and pituitary-specific mRNA that encodes a novel chromogranin/secretogranin-like component of intracellular vesicles
HP Ottiger, EF Battenberg, AP Tsou, FE Bloom and JG Sutcliffe
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.
The rat 1B1075 mRNA encodes a 533-residue novel
chromogranin/secretogranin-like acidic protein that contains an apparent
secretion signal, several pairs of tandem basic residues, and internally
repeated sequence elements. 1B1075 transcripts are detected, by blotting
and in situ hybridization, at the highest levels in the neocortex,
hippocampus, cerebellar cortex, selected pontine and diencephalic nuclei,
and presumptive pituitary corticotrophs, at lower levels in specific nuclei
in most other brain regions, but in none of several other tissues.
Utilizing antisera to several nonoverlapping synthetic peptide fragments of
the predicted protein sequence, we detect a brain- and pituitary-specific
57-kDa protein in cellular processes and fiber tracts, generally consistent
with axonal transport from the cell bodies identified by in situ
hybridization. Ultrastructural studies demonstrate that this protein is a
component of intraneuronal vesicles in axons and vesicle-like structures in
dendrites. Based on these data, we suggest the name Secretogranin III for
the 1B1075 gene product. In related collaborative studies, a mouse deleted
for the 1B1075-homologous gene has been produced that should allow
assessment of its physiological role.
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