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Journal of Neuroscience, Vol 11, 210-225, Copyright © 1991 by Society for Neuroscience
Histochemical and immunocytochemical compartments of the thalamic VPM nucleus in monkeys and their relationship to the representational map
E Rausell and EG Jones
Department of Anatomy and Neurobiology, University of California 92717.
The ventral posteromedial nucleus (VPM) of the monkey thalamus was
investigated with correlative anatomical and physiological techniques. On
the basis of staining for cytochrome oxidase (CO), VPM is divided into a
lightly stained, background matrix domain and an intensely stained rod
domain. The latter consists of elongated rods of large, medium, and small
cells, 500 microns wide on average and extending anteroposteriorly, many of
them through the full extent of the nucleus. The matrix, consisting of
small cells, penetrates between the rods and expands at the dorsomedial,
ventrolateral, and posterior aspects of VPM. Multiunit mapping reveals that
VPM contains a dorsally situated representation of the contralateral side
of the head, face, eye, and interior of the mouth and a medially situated
representation of the ipsilateral side of the lips and interior of the
mouth, and that the same small region is represented in the same relative
position through the full anteroposterior extent of the nucleus. Earlier
work had shown that single CO rods contain the representation of the same
portion of the periphery throughout their length. The present study
suggests that rods in equivalent positions may represent the same portion
of the periphery from animal to animal. The cells of the rod and matrix
domains show different patterns of immunoreactivity. Virtually all of the
large- and medium-sized rod cells are immunoreactive for the
calcium-binding protein parvalbumin, and many are stained by the monoclonal
antibody CAT 301. Small GABA-immunoreactive cells and terminal-like puncta
are highly concentrated in the rods but are dispersed in the matrix. In the
matrix, all non-GABA cells are small, immunoreactive for 28-kDa calbindin,
and not stained by CAT 301. They appear to form part of a wider system of
calbindin-positive cells that extends into adjacent nuclei. The CO rods are
indicative of the modularity of the lemniscal component of the trigeminal
part of the somatic sensory system at thalamic levels. Thalamocortical
relay neurons in this compartment of VPM express a calcium-binding protein
and a surface proteoglycan that distinguishes them from relay neurons in
the matrix compartment of the nucleus. In the following paper (Rausell and
Jones, 1991), the rod and matrix compartments are shown also to have
different patterns of input and output connections.
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