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Journal of Neuroscience, Vol 11, 85-95, Copyright © 1991 by Society for Neuroscience
Continuous repetitive stimuli are more effective than bursts for evoking LHRH release in bullfrog sympathetic ganglia
YY Peng and JP Horn
Department of Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261.
Effects of different patterns of presynaptic stimulation upon release of
leuteinizing hormone releasing hormone (LHRH) were studied by monitoring
LHRH-induced slow currents from individual postsynaptic neurons in bullfrog
sympathetic ganglia. LHRH-mediated synaptic currents in ganglionic B and C
neurons were recorded by a single- electrode voltage-clamp technique. Using
continuous stimulation, release increased with frequency between 2 and 20
Hz, then declined. Though bursts of stimuli always evoked more release than
continuous stimuli of the same average frequency, they were invariably less
effective than continuous stimulation at the intraburstal frequency. This
demonstrates that frequency, not bursting structure, governs peptide
release. The dependence of release upon stimulus frequency was altered when
extracellular Ca2+ concentration was changed, implying that release does
not depend intrinsically upon stimulation frequency, but simply on the
availability of Ca2+.
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