 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 11, 2985-2994, Copyright © 1991 by Society for Neuroscience
Muller cells are a preferred substrate for in vitro neurite extension by rod photoreceptor cells
IJ Kljavin and TA Reh
Faculty of Medicine, Lion's Sight Center, University of Calgary, Alberta, Canada.
To define the factors important in photoreceptor cell morphogenesis, we
have examined the ability of rods to extend neurites in vitro. Retinas from
neonatal rats were dissociated and plated onto substrate-bound
extracellular matrix (ECM) components or cell monolayers. When rods,
identified with monoclonal antibodies to opsin, were in contact exclusively
with purified ECM (e.g., laminin, fibronectin, type I collagen, or
Matrigel), neurite outgrowth was extremely limited. By contrast, rods
extended long neurites on Muller cells. Retinal or brain astrocytes,
endothelial cells, 3T3 fibroblasts, or other retinal neurons were less
supportive of rod process outgrowth. These data demonstrate regional
specificity in the promotion of neurite outgrowth by glia and suggest that
not all neurons within the retina require the same morphogenic factors.
This article has been cited by other articles:
|
|
|
|
 
F. Ghosh, K. Arner, and K. Engelsberg
Isolation of Photoreceptors in the Cultured Full-Thickness Fetal Rat Retina
Invest. Ophthalmol. Vis. Sci.,
February 1, 2009;
50(2):
826 - 835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Sethi, G. P. Lewis, S. K. Fisher, W. P. Leitner, D. L. Mann, P. J. Luthert, and D. G. Charteris
Glial Remodeling and Neural Plasticity in Human Retinal Detachment with Proliferative Vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.,
January 1, 2005;
46(1):
329 - 342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Balse, L.-H. Tessier, C. Fuchs, V. Forster, J. A. Sahel, and S. Picaud
Purification of Mammalian Cone Photoreceptors by Lectin Panning and the Enhancement of Their Survival in Glia-Conditioned Medium
Invest. Ophthalmol. Vis. Sci.,
January 1, 2005;
46(1):
367 - 374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Limb, T. E. Salt, P. M. G. Munro, S. E. Moss, and P. T. Khaw
In Vitro Characterization of a Spontaneously Immortalized Human Muller Cell Line (MIO-M1)
Invest. Ophthalmol. Vis. Sci.,
March 1, 2002;
43(3):
864 - 869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Inoue, S. Yamamoto, M. Okada, M. Tsujikawa, T. Inoue, A. A. Okada, S. Kusaka, Y. Saito, K. Wakabayashi, Y. Miyake, et al.
X-Linked Retinoschisis With Point Mutations in the XLRS1 Gene
Arch Ophthalmol,
January 1, 2000;
118(1):
93 - 96.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Picaud, B. Pattnaik, D. Hicks, V. Forster, V. Fontaine, J. Sahel, and H. Dreyfus
GABAA and GABAC receptors in adult porcine cones: evidence from a photoreceptor-glia co-culture model
J. Physiol.,
November 15, 1998;
513(1):
33 - 42.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Levine, H. Roelink, J. Turner, and T. A. Reh
Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro
J. Neurosci.,
August 15, 1997;
17(16):
6277 - 6288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O Bermingham-McDonogh, K. McCabe, and T. Reh
Effects of GGF/neuregulins on neuronal survival and neurite outgrowth correlate with erbB2/neu expression in developing rat retina
Development,
January 5, 1996;
122(5):
1427 - 1438.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Kelley, J. Turner, and T. Reh
Retinoic acid promotes differentiation of photoreceptors in vitro
Development,
January 8, 1994;
120(8):
2091 - 2102.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B Poeck, A Hofbauer, and G. Pflugfelder
Expression of the Drosophila optomotor-blind gene transcript in neuronal and glial cells of the developing nervous system
Development,
January 3, 1993;
117(3):
1017 - 1029.
[Abstract]
[PDF]
|
|
|
|
|
