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Journal of Neuroscience, Vol 11, 3442-3455, Copyright © 1991 by Society for Neuroscience
Transient IGF-I gene expression during the maturation of functionally related central projection neurons
CA Bondy
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
Insulin-like growth factor I (IGF-I) is a monomeric peptide with
significant homology to proinsulin. IGF-I has a number of potent effects on
cultured neural tissue, including the stimulation of mitosis in sympathetic
neuroblasts; the promotion of neurite outgrowth in cortical, sensory, and
sympathetic neurons; and the induction of oligodendrocyte differentiation.
In order to determine the sites in which IGF-I may play a role in neural
development in vivo, the pattern of IGF-I gene expression in the developing
rat brain has been analyzed by means of in situ hybridization
histochemistry. Transient IGF-I gene expression is seen during the
maturation of specific groups of functionally related sensory and
cerebellar projection neurons. IGF-I mRNA is abundant within developing
cerebellar Purkinje cells and in the major cerebellar relay centers,
including the inferior olive, medial vestibular and lateral reticular
nuclei of the brainstem, and the deep cerebellar and red nuclei. Similarly,
IGF-I mRNA is localized in the synaptic stations of the developing
olfactory, auditory, visual, and somatosensory systems. For example, in the
auditory system, IGF-I mRNA is abundant in the cochlear nucleus, superior
olive, lateral lemniscus, medial geniculate body, and inferior colliculus.
In each system, IGF-I gene expression is found predominantly in long-axon
projection neurons, appearing during a relatively late stage in their
development, at a time of maturation of dendrites and synapse formation.
The specific timing and selective localization of neuronal IGF-I gene
expression described in this study suggest that IGF-I may have a role in
the shaping of system-specific synaptic connections or myelinization.
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