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Journal of Neuroscience, Vol 11, 3556-3564, Copyright © 1991 by Society for Neuroscience
Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography
M Schwartz Levey, DM Chikaraishi and JS Kauer
Neuroscience Program, Tufts-New England Medical Center, Boston, Massachusetts 02111.
There are at least two basal cell populations in the olfactory epithelium
that could give rise to olfactory neurons during development, in the normal
adult, and after experimentally induced receptor cell death. These
populations have been subdivided as horizontal (HBC) and globose (GBC)
basal cells on the basis of morphological criteria and by staining with
antibodies against cytokeratin. HBCs are positive for cytokeratin while
GBCs are negative. We have studied which cell type is induced to divide
during receptor cell regeneration stimulated by olfactory bulbectomy using
a combination of immunocytochemistry and autoradiography. By examining
which population increases its labeling index with 3H-thymidine (3H- TdR)
at various times after bulbectomy, it is shown that there is an increase in
3H-TdR uptake in the cytokeratin-negative GBCs with no change in the
cytokeratin-positive HBCs. This suggests that the GBCs are specifically
induced to divide in response to cues that accompany receptor cell death,
and it is thus concluded that these cells are among the precursors of new
olfactory receptor neurons.
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