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Journal of Neuroscience, Vol 11, 392-400, Copyright © 1991 by Society for Neuroscience
Estrogen-enhanced neurite growth: evidence for a selective induction of Tau and stable microtubules
A Ferreira and A Caceres
Instituto de Investigacion Medica Mercedes y Martin Ferreyra, Cordoba, Argentina.
Estrogen stimulates the neurite outgrowth response of medial basal
hypothalamic neurons maintained in culture. We show here that one effect of
estrogen is to promote an increase in tau, but not in tubulin,
microtubule-associated protein 1a (MAP-1a), or MAP-2 protein levels. This
response precedes and accompanies an increase in stable microtubules and in
neurite length. Taken collectively, our data suggest that estrogen-enhanced
neurite growth is mediated by a selective induction of
microtubule-stabilizing factors, namely, the tau proteins.
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