 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 11, 519-533, Copyright © 1991 by Society for Neuroscience
The early commitment of fetal neurons to the limbic cortex
MF Barbe and P Levitt
Department of Anatomy and Neurobiology, Medical College of Pennsylvania, Philadelphia 19129.
The limbic-system-associated membrane protein (LAMP) is expressed early in
cerebral cortical development by migrating and postmigratory neurons in
limbic regions such as the prefrontal and perirhinal cortices (Horton and
Levitt, 1988), but not by nonlimbic neurons such as in the primary sensory
and motor cortices. In the present study, we used LAMP expression to
evaluate the timing and potential cell-lineage and environmental
determinants of the commitment of cerebral cortical neurons to limbic and
nonlimbic phenotypes. The cerebral wall, containing either presumptive
perirhinal or sensorimotor cortex, was removed prior to [embryonic day (E)
12, 14] or just after (E17) the onset of LAMP expression, labeled with fast
blue, and placed into cavities in either perirhinal or sensorimotor regions
of postnatal day (P) 1 hosts. Host animals were allowed to survive until at
least P10, and surviving transplanted cells were counted and evaluated for
LAMP expression. Sensorimotor cortical neurons transplanted at E14 or E17,
in either homotopic or heterotopic locations, did not express LAMP. In
contrast, a high percentage of perirhinal cortical neurons transplanted at
either E14 or E17, whether situated in sensorimotor or perirhinal regions
of the host, expressed the limbic marker protein. Surprisingly, neurons
from E12 donors exhibited patterns of LAMP expression that reflected their
new location in the host rather than their embryonic origin. The data
suggest that there is an early pliant period in which precursor and early
differentiating cells remain uncommitted to a particular cortical regional
phenotype. After this period, one aspect of the molecular phenotype
(determined by LAMP expression) of neurons destined for sensorimotor and
allo- and mesocortical regions has become immutable by environmental
factors in the host.
This article has been cited by other articles:
|
|
|
|
 
S. N. Sansom and F. J. Livesey
Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex
Cold Spring Harb Perspect Biol,
August 1, 2009;
1(2):
a002519 - a002519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. Kudo, S. L. Karsten, J. Chen, P. Levitt, and D. H. Geschwind
Genetic Analysis of Anterior Posterior Expression Gradients in the Developing Mammalian Forebrain
Cereb Cortex,
September 1, 2007;
17(9):
2108 - 2122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Leto, B. Carletti, I. M. Williams, L. Magrassi, and F. Rossi
Different Types of Cerebellar GABAergic Interneurons Originate from a Common Pool of Multipotent Progenitor Cells.
J. Neurosci.,
November 8, 2006;
26(45):
11682 - 11694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Bai, M. Ishida, M. Okabe, and Y. Arimatsu
Role of the Protomap and Target-derived Signals in the Development of Intrahemispheric Connections
Cereb Cortex,
January 1, 2006;
16(1):
124 - 135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Land and A. P. Monaghan
Expression of the Transcription Factor, tailless, Is Required for Formation of Superficial Cortical Layers
Cereb Cortex,
September 1, 2003;
13(9):
921 - 931.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Muzio and A. Mallamaci
Emx1, Emx2 and Pax6 in Specification, Regionalization and Arealization of the Cerebral Cortex
Cereb Cortex,
June 1, 2003;
13(6):
641 - 647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bellion, M. Wassef, and C. Metin
Early Differences in Axonal Outgrowth, Cell Migration and GABAergic Differentiation Properties between the Dorsal and Lateral Cortex
Cereb Cortex,
February 1, 2003;
13(2):
203 - 214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Carletti, P. Grimaldi, L. Magrassi, and F. Rossi
Specification of Cerebellar Progenitors After Heterotopic-Heterochronic Transplantation to the Embryonic CNS In Vivo and In Vitro
J. Neurosci.,
August 15, 2002;
22(16):
7132 - 7146.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. H.M. Smart, C. Dehay, P. Giroud, M. Berland, and H. Kennedy
Unique Morphological Features of the Proliferative Zones and Postmitotic Compartments of the Neural Epithelium Giving Rise to Striate and Extrastriate Cortex in the Monkey
Cereb Cortex,
January 1, 2002;
12(1):
37 - 53.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Polleux, C. Dehay, A. Goffinet, and H. Kennedy
Pre- and Post-mitotic Events Contribute to the Progressive Acquisition of Area-specific Connectional Fate in the Neocortex
Cereb Cortex,
November 1, 2001;
11(11):
1027 - 1039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Tomioka, N. Osumi, Y. Sato, T. Inoue, S. Nakamura, H. Fujisawa, and T. Hirata
Neocortical Origin and Tangential Migration of Guidepost Neurons in the Lateral Olfactory Tract
J. Neurosci.,
August 1, 2000;
20(15):
5802 - 5812.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Gaillard and M. Roger
Early Commitment of Embryonic Neocortical Cells to Develop Area-specific Thalamic Connections
Cereb Cortex,
May 1, 2000;
10(5):
443 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Soria and A. Fairen
Cellular Mosaics in the Rat Marginal Zone Define an Early Neocortical Territorialization
Cereb Cortex,
April 1, 2000;
10(4):
400 - 412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Lee, S Tole, E Grove, and A. McMahon
A local Wnt-3a signal is required for development of the mammalian hippocampus
Development,
January 2, 2000;
127(3):
457 - 467.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. Nakagawa, J. E. Johnson, and D. D. M. O'Leary
Graded and Areal Expression Patterns of Regulatory Genes and Cadherins in Embryonic Neocortex Independent of Thalamocortical Input
J. Neurosci.,
December 15, 1999;
19(24):
10877 - 10885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L.R. Rubenstein, S. Anderson, L. Shi, E. Miyashita-Lin, A. Bulfone, and R. Hevner
Genetic Control of Cortical Regionalization and Connectivity
Cereb Cortex,
September 1, 1999;
9(6):
524 - 532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Eagleson and P. Levitt
Complex Signaling Responsible for Molecular Regionalization of the Cerebral Cortex
Cereb Cortex,
September 1, 1999;
9(6):
562 - 568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Gitton, M. Cohen-Tannoudji, and M. Wassef
Role of Thalamic Axons in the Expression of H-2Z1, a Mouse Somatosensory Cortex Specific Marker
Cereb Cortex,
September 1, 1999;
9(6):
611 - 620.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Donoghue and P. Rakic
Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
J. Neurosci.,
July 15, 1999;
19(14):
5967 - 5979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Gitton, M. Cohen-Tannoudji, and M. Wassef
Specification of Somatosensory Area Identity in Cortical Explants
J. Neurosci.,
June 15, 1999;
19(12):
4889 - 4898.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Arimatsu, M Ishida, K Takiguchi-Hayashi, and Y Uratani
Cerebral cortical specification by early potential restriction of progenitor cells and later phenotype control of postmitotic neurons
Development,
January 2, 1999;
126(4):
629 - 638.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. Polleux, C. Dehay, and H. Kennedy
Neurogenesis and Commitment of Corticospinal Neurons in reeler
J. Neurosci.,
December 1, 1998;
18(23):
9910 - 9923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Tole, C Christian, and E. Grove
Early specification and autonomous development of cortical fields in the mouse hippocampus
Development,
January 12, 1997;
124(24):
4959 - 4970.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Reid, S. Tavazoie, and C. Walsh
Clonal dispersion and evidence for asymmetric cell division in ferret cortex
Development,
January 6, 1997;
124(12):
2441 - 2450.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Eagleson, L Lillien, A. Chan, and P Levitt
Mechanisms specifying area fate in cortex include cell-cycle-dependent decisions and the capacity of progenitors to express phenotype memory
Development,
January 4, 1997;
124(8):
1623 - 1630.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y Nakagawa, T Kaneko, T Ogura, T Suzuki, M Torii, K Kaibuchi, K Arai, S Nakamura, and M Nakafuku
Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells
Development,
January 8, 1996;
122(8):
2449 - 2464.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. R. Kriegstein
Cell-Cell Signaling in Early Cortical Development
Neuroscientist,
September 1, 1995;
1(5):
268 - 276.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Ferri and P Levitt
Regulation of regional differences in the differentiation of cerebral cortical neurons by EGF family-matrix interactions
Development,
January 4, 1995;
121(4):
1151 - 1160.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Fishell
Striatal precursors adopt cortical identities in response to local cues
Development,
January 3, 1995;
121(3):
803 - 812.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A Ghosh and C. Shatz
A role for subplate neurons in the patterning of connections from thalamus to neocortex
Development,
January 3, 1993;
117(3):
1031 - 1047.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Shatz
Dividing up the neocortex
Science,
October 9, 1992;
258(5080):
237 - 238.
[PDF]
|
|
|
|
|
|
|
C Walsh and C. Cepko
Widespread dispersion of neuronal clones across functional regions of the cerebral cortex
Science,
January 24, 1992;
255(5043):
434 - 440.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Fukuchi-Shimogori and E. A. Grove
Neocortex Patterning by the Secreted Signaling Molecule FGF8
Science,
November 2, 2001;
294(5544):
1071 - 1074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
