WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Introducing ALZET?ew Model 2006 Pump
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Plessers, L.
Right arrow Articles by Casteels, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Plessers, L.
Right arrow Articles by Casteels, R.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 11, 650-656, Copyright © 1991 by Society for Neuroscience

ARTICLE

A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons

L Plessers, JA Eggermont, F Wuytack and R Casteels
Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholicke Universiteit Leuven, Belgium.

Pig cerebellar Purkinje neurons express a high level of Ca2(+)- transport ATPases in their intracellular Ca2+ stores. This was shown at the mRNA level by Northern blotting and in situ hybridization and at the protein level by Western blotting and immunocytochemistry. The majority of the Ca2(+)-transport ATPases in these neurons belongs to the SERCA2b type (i.e., the Ca2(+)-pump isoform found in most nonmuscle cells). The SERCA2a (cardiac/slow-twitch skeletal/smooth muscle) Ca2(+)- pump isoform is expressed only at very low levels. The main Ca2(+)-pump messenger is 6.0 kilobases long and belongs to a class 4-type processing of SERCA2, which is exclusively confined to the cerebrum and cerebellum. Phospholamban, a regulator of the SERCA2 Ca2(+)-transport ATPase in cardiac/slow-twitch skeletal/smooth muscle, could not be detected in Purkinje neurons.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
D. S. Carter, S. N. Haider, R. E. Blair, L. S. Deshpande, S. Sombati, and R. J. DeLorenzo
Altered Calcium/Calmodulin Kinase II Activity Changes Calcium Homeostasis That Underlies Epileptiform Activity in Hippocampal Neurons in Culture
J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1021 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S.-G. Lu, X. Zhang, and M. S. Gold
Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons
J. Physiol., November 15, 2006; 577(1): 169 - 190.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. M. Usachev, A. J. Marsh, T. M. Johanns, M. M. Lemke, and S. A. Thayer
Activation of Protein Kinase C in Sensory Neurons Accelerates Ca2+ Uptake into the Endoplasmic Reticulum
J. Neurosci., January 4, 2006; 26(1): 311 - 318.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Mertens, L. V. D. Bosch, H. Verboomen, F. Wuytack, H. D. Smedt, and J. Eggermont
Sequence and Spatial Requirements for Regulated Muscle-specific Processing of the Sarco/Endoplasmic Reticulum Ca[IMAGE]-ATPase 2 Gene Transcript
J. Biol. Chem., May 5, 1995; 270(18): 11004 - 11011.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-