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Journal of Neuroscience, Vol 11, 709-721, Copyright © 1991 by Society for Neuroscience
Channeling of developing rat corticospinal tract axons by myelin- associated neurite growth inhibitors
ME Schwab and L Schnell
Institute for Brain Research, University of Zurich, Switzerland.
CNS myelin contains 2 membrane proteins that are potent inhibitors of
neurite growth (NI-35 and NI-250). Because myelin formation starts at
different times in different regions and tracts of the CNS, this inhibitory
property of myelin could serve boundary and guidance functions for
late-growing fiber tracts. In the rat, the corticospinal tract (CST) grows
into and down the spinal cord during the first 10 postnatal days, in close
proximity to the sensory tracts fasciculus cuneatus and gracilis.
Immunofluorescence for myelin constituents showed that, in the rostral half
of the spinal cord, the myelinating tissue of these ascending tracts
surrounds the growing, myelin-free CST in a channellike fashion.
Elimination of oligodendrocytes by x- irradiation of the newborn rats, or
application of antibody IN-1, which neutralizes the inhibitory substrate
property of CNS myelin, resulted in significant anatomical aberration of
CST fibers. In particular, the tract was larger in cross-section, and
aberrant CST fibers and fascicles intermixed with the neighboring sensory
ascending tracts. These results assign an important channeling and
"guard-rail" function to the oligodendrocyte-associated neurite growth
inhibitors for the developing CST in the rat spinal cord.
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