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Journal of Neuroscience, Vol 11, 869-880, Copyright © 1991 by Society for Neuroscience
A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties
MD Pak, M Covarrubias, A Ratcliffe and L Salkoff
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110.
We have cloned and expressed a mouse brain K+ channel that is the homolog
of the Drosophila Shab K+ channel. Mouse and Drosophila Shab K+ channels
(mShab and fShab, respectively) represent an instance of K+ channels and
structurally related species that are both functionally and structurally
conserved; most kinetic, voltage-sensitive, and pharmacological properties
are similar for the 2 channels. The greatest functional difference between
the currents is recovery from inactivation, which is several times slower
for mShab than for fShab currents. In addition to conserved structure, the
mShab polypeptide has an unusually long nonconserved region at the carboxyl
end of the protein. Truncation of 293 residues from the carboxyl end
produced no noticeable change in voltage-sensitive, kinetic, or
pharmacological properties. Thus, the measured functional properties of
mShab are determined by the remaining 564 residues, most of which are
conserved. The mShab and fShab channels are naturally occurring structural
variants having substitutions in conserved portions that appear relatively
neutral with respect to all measured properties except for, possibly, the
rate of recovery from inactivation. The mShab current closely resembles a
native delayed-rectifier-type potassium current, IK, in hippocampal
neurons.
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