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Journal of Neuroscience, Vol 11, 1577-1584, Copyright © 1991 by Society for Neuroscience
Transient and persistent expression of NT-3/HDNF mRNA in the rat brain during postnatal development
WJ Friedman, P Ernfors and H Persson
Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden.
Neurotrophin-3 (NT-3) is closely related to two known neurotrophic agents,
NGF and brain-derived neurotrophic factor (BDNF), and acts upon
overlapping, yet distinct, populations of peripheral ganglia. NT-3 mRNA
expression in the adult rat brain is largely confined to the hippocampus.
In this study, we have used in situ hybridization to examine expression of
this novel neurotrophic factor during postnatal development. The striking
observation was made that NT-3 mRNA was transiently expressed at high
levels in the cingulate cortex during the first 2 weeks of age. In the
hippocampus, the adult pattern of expression, in the CA2, medial CA1, and
granule layer of the dentate gyrus, was detected at all ages examined.
However, there were two major differences in NT-3 mRNA expression in the
developing hippocampus: Labeled cells were detected in the hilar region of
the dentate gyrus at postnatal day 1 (P1) and 1 week that were absent by 2
weeks of age. Further, the caudal hippocampus, which has a lower intensity
of labeling than the rostral region in the adult, was devoid of NT-3-
expressing cells in the P1 and 1-week-old rat brain. These data indicate a
substantial plasticity in NT-3 mRNA expression and suggest that the
spectrum of neurons supported by NT-3 during development is partially
different from that in the mature rat brain.
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