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Journal of Neuroscience, Vol 11, 2288-2294, Copyright © 1991 by Society for Neuroscience
Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons
M Joels, W Hesen and ER de Kloet
Division of Molecular Biology, University of Utrecht, The Netherlands.
Pyramidal neurons in the rat CA1 hippocampal area contain intracellular
mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) to
which the adrenal hormone corticosterone can bind with differential
affinity. The pyramidal neurons also have high amounts of 5-HT1a receptors,
which mediate a membrane hyperpolarization. With intracellular recording in
vitro, we found that selective occupation of MRs suppresses the
5-HT-induced hyperpolarization of CA1 pyramidal neurons. The suppression of
5-HT responses was observed 1-4 hr after a brief (20-min) application of
the steroids. Binding properties of the 5- HT1a receptor were not
significantly affected by in vitro steroid application. Furthermore,
responses to the GABAB agonist baclofen were not changed after treatment
with MR ligands, implying that the K+ conductance to which both GABAB and
5-HT1a receptors are linked is also no target for the steroid action. The
MR-mediated effect on 5-HT responsiveness potentially enhances cellular
activity. Because activation of GRs was previously found to suppress
norepinephrine- induced excitability in the same neurons, the data support
the concept that cellular homeostasis in the hippocampus is under control
of corticosterone via coordinative, antagonistic MR- and GR-mediated
events.
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