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Journal of Neuroscience, Vol 11, 2644-2654, Copyright © 1991 by Society for Neuroscience
The origin of thalamic inputs to the "hand" representation in the primary motor cortex
JW Holsapple, JB Preston and PL Strick
Department of Neurosurgery, SUNY Health Science Center, Syracuse 13210.
We used retrograde transport of WGA-HRP to examine the origin of thalamic
inputs to the "hand" representation in the primary motor cortex of macaques
(Macaca nemestrina). Injections were placed in either the crest of the
precentral gyrus or the rostral bank of the central sulcus. The sites for
injection in the sulcus were determined by using intracortical stimulation
to map the location of hand representation. We found that the precentral
gyrus and central sulcus receive their predominant input from different
subdivisions of the ventrolateral thalamus. Ventralis posterior lateralis
pars oralis (VPLo) provides the most substantial input to a portion of the
hand representation on the gyrus. In contrast, Ventralis lateralis pars
oralis (VLo) provides the most substantial input to a portion of the hand
representation in the sulcus. Prior studies have shown that VPLo is a major
site of termination of cerebellar efferents and that VLo is a major site of
termination of pallidal efferents. Thus, our results indicate that both the
basal ganglia and the cerebellum "directly" influence the "hand"
representation of the primary motor cortex.
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