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Journal of Neuroscience, Vol 12, 4037-4044, Copyright © 1992 by Society for Neuroscience
Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat
ES Levine and BL Jacobs
Department of Psychology, Princeton University, New Jersey 08544.
Serotonergic (5-HT) neurons of the brainstem dorsal raphe nucleus (DRN)
have been implicated in a diversity of physiological and behavioral
processes in vertebrates. However, despite extensive information about the
intrinsic properties and the efferent projections of this neurochemical
system, little information is available regarding the afferents that
control its activity. This study investigated the neurotransmitters that
regulate the activity of DRN-5-HT neurons under physiologically relevant
conditions, by utilizing microiontophoresis in combination with single-unit
recordings in the awake, head-restrained cat. This made it possible to
examine the direct effects of neurotransmitters on DRN-5-HT neuronal
activity, and, through the use of specific antagonists, to study the roles
of these neurotransmitter inputs during physiological conditions that
influence DRN-5-HT neuronal activity. The results indicate that (1)
iontophoretic application of the GABA antagonist bicuculline reversed the
typical suppression of neuronal activity seen during slow wave sleep, but
had no effect on maintained activity during wakefulness. The suppression of
neuronal activity during REM sleep was generally unaffected by application
of bicuculline. This suggests a role for a GABAergic input to DRN-5-HT
neurons in controlling some aspects of their state-dependent activity. (2)
Iontophoretic application of the excitatory amino acid (EAA) antagonist
kynurenic acid reduced the magnitude of the neuronal response evoked by
phasic auditory stimuli, but had no effect on the spontaneous activity of
these neurons, suggesting a role for an EAA input to the DRN in mediating
the response to phasic sensory stimuli.(ABSTRACT TRUNCATED AT 250 WORDS)
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