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Journal of Neuroscience, Vol 12, 4510-4520, Copyright © 1992 by Society for Neuroscience

ARTICLE

Muscarinic potentiation of IK in hippocampal neurons: electrophysiological characterization of the signal transduction pathway

L Zhang, JL Weiner and PL Carlen
Playfair Neuroscience Unit, Toronto Hospital Research Institute, Ontario, Canada.

Central cholinergic (muscarinic) systems play an important role in learning and memory. In mammalian central neurons, muscarinic stimulation depresses several voltage-activated K+ currents and modulates synaptic transmission. Using whole-cell voltage-clamp recordings in hippocampal CA1 neurons of rat brain slices, we report that activation of muscarinic receptors potentiates a voltage- activated, sustained K+ current (IK-type). This potentiation of IK is mediated by activation of protein kinase C and involves a G-protein- linked, intracellular Ca(2+)-dependent process. This underlying second messenger pathway may prove to be important in the mediation of other previously reported muscarinic neuronal actions.

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