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Journal of Neuroscience, Vol 12, 4565-4574, Copyright © 1992 by Society for Neuroscience

ARTICLE

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

BA Reynolds, W Tetzlaff and S Weiss
Department of Anatomy, University of Calgary Faculty of Medicine, Alberta, Canada.

The mitogenic actions of epidermal growth factor (EGF) were examined in low-density, dissociated cultures of embryonic day 14 mouse striatal primordia, under serum-free defined conditions. EGF induced the proliferation of single progenitor cells that began to divide between 5 and 7 d in vitro, and after 13 d in vitro had formed a cluster of undifferentiated cells that expressed nestin, an intermediate filament present in neuroepithelial stem cells. In the continued presence of EGF, cells migrated from the proliferating core and differentiated into neurons and astrocytes. The actions of EGF were mimicked by the homolog transforming growth factor alpha (TGF alpha), but not by NGF, basic fibroblast growth factor, platelet-derived growth factor, or TGF beta. In EGF-generated cultures, cells with neuronal morphology contained immunoreactivity for GABA, substance P, and methionine-enkephalin, three neurotransmitters of the adult striatum. Amplification of embryonic day 14 striatal mRNA by using reverse transcription/PCR revealed mRNAs for EGF, TGF alpha, and the EGF receptor. These findings suggest that EGF and/or TGF alpha may act on a multipotent progenitor cell in the striatum to generate both neurons and astrocytes.


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P. Ciana, S. Ghisletti, P. Mussi, I. Eberini, E. Vegeto, and A. Maggi
Estrogen Receptor {alpha}, a Molecular Switch Converting Transforming Growth Factor-{alpha}-mediated Proliferation into Differentiation in Neuroblastoma Cells
J. Biol. Chem., August 22, 2003; 278(34): 31737 - 31744.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
D. Kaushal, J. J. A. Contos, K. Treuner, A. H. Yang, M. A. Kingsbury, S. K. Rehen, M. J. McConnell, M. Okabe, C. Barlow, and J. Chun
Alteration of Gene Expression by Chromosome Loss in the Postnatal Mouse Brain
J. Neurosci., July 2, 2003; 23(13): 5599 - 5606.
[Abstract] [Full Text] [PDF]

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 J BiochemHome page
N. Amada, T. Tezuka, A. Mayeda, K. Araki, N. Takei, K. Todokoro, and H. Nawa
A Novel Rat Orthologue and Homologue for the Drosophila crooked neck Gene in Neural Stem Cells and Their Immediate Descendants
J. Biochem., May 1, 2003; 133(5): 615 - 623.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Dono
Fibroblast growth factors as regulators of central nervous system development and function
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R867 - R881.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
K. C. Luk, T. E. Kennedy, and A. F. Sadikot
Glutamate Promotes Proliferation of Striatal Neuronal Progenitors by an NMDA Receptor-Mediated Mechanism
J. Neurosci., March 15, 2003; 23(6): 2239 - 2250.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
G. Kempermann, D. Gast, G. Kronenberg, M. Yamaguchi, and F. H. Gage
Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
Development, March 2, 2003; 130(2): 391 - 399.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
A. Chojnacki, T. Shimazaki, C. Gregg, G. Weinmaster, and S. Weiss
Glycoprotein 130 Signaling Regulates Notch1 Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells
J. Neurosci., March 1, 2003; 23(5): 1730 - 1741.
[Abstract] [Full Text] [PDF]

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 FASEB J.Home page
Y. ZHU, K. JIN, X. O. MAO, and D. A. GREENBERG
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression
FASEB J, February 1, 2003; 17(2): 186 - 193.
[Abstract] [Full Text] [PDF]

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 J. Histochem. Cytochem.Home page
M. V.T. Lobo, F. J. M. Alonso, C. Redondo, M. A. Lopez-Toledano, E. Caso, A. S. Herranz, C. L. Paino, D. Reimers, and E. Bazan
Cellular Characterization of Epidermal Growth Factor-expanded Free-floating Neurospheres
J. Histochem. Cytochem., January 1, 2003; 51(1): 89 - 103.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
K. Jin, Y. Zhu, Y. Sun, X. O. Mao, L. Xie, and D. A. Greenberg
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
PNAS, September 3, 2002; 99(18): 11946 - 11950.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
N. Duval, D. Gomes, V. Calaora, A. Calabrese, P. Meda, and R. Bruzzone
Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells
J. Cell Sci., August 15, 2002; 115(16): 3241 - 3251.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
K. Jin, X. O. Mao, Y. Sun, L. Xie, L. Jin, E. Nishi, M. Klagsbrun, and D. A. Greenberg
Heparin-Binding Epidermal Growth Factor-Like Growth Factor: Hypoxia-Inducible Expression In Vitro and Stimulation of Neurogenesis In Vitro and In Vivo
J. Neurosci., July 1, 2002; 22(13): 5365 - 5373.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
S. Hitoshi, T. Alexson, V. Tropepe, D. Donoviel, A. J. Elia, J. S. Nye, R. A. Conlon, T. W. Mak, A. Bernstein, and D. van der Kooy
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
Genes & Dev., April 1, 2002; 16(7): 846 - 858.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. Hitoshi, V. Tropepe, M. Ekker, and D. van der Kooy
Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain
Development, January 1, 2002; 129(1): 233 - 244.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
T. Shingo, S. T. Sorokan, T. Shimazaki, and S. Weiss
Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells
J. Neurosci., December 15, 2001; 21(24): 9733 - 9743.
[Abstract] [Full Text] [PDF]

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 IOVSHome page
S. Pressmar, M. Ader, G. Richard, M. Schachner, and U. Bartsch
The Fate of Heterotopically Grafted Neural Precursor Cells in the Normal and Dystrophic Adult Mouse Retina
Invest. Ophthalmol. Vis. Sci., December 1, 2001; 42(13): 3311 - 3319.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
W. He, C. Ingraham, L. Rising, S. Goderie, and S. Temple
Multipotent Stem Cells from the Mouse Basal Forebrain Contribute GABAergic Neurons and Oligodendrocytes to the Cerebral Cortex during Embryogenesis
J. Neurosci., November 15, 2001; 21(22): 8854 - 8862.
[Abstract] [Full Text] [PDF]

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 BloodHome page
C.-C. Shih, Y. Weng, A. Mamelak, T. LeBon, M. C.-T. Hu, and S. J. Forman
Identification of a candidate human neurohematopoietic stem-cell population
Blood, October 15, 2001; 98(8): 2412 - 2422.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
T. Shimazaki, T. Shingo, and S. Weiss
The Ciliary Neurotrophic Factor/Leukemia Inhibitory Factor/gp130 Receptor Complex Operates in the Maintenance of Mammalian Forebrain Neural Stem Cells
J. Neurosci., October 1, 2001; 21(19): 7642 - 7653.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
Y. Arsenijevic, S. Weiss, B. Schneider, and P. Aebischer
Insulin-Like Growth Factor-I Is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2
J. Neurosci., September 15, 2001; 21(18): 7194 - 7202.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
V. Pencea, K. D. Bingaman, S. J. Wiegand, and M. B. Luskin
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus
J. Neurosci., September 1, 2001; 21(17): 6706 - 6717.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
V. Calaora, B. Rogister, K. Bismuth, K. Murray, H. Brandt, P. Leprince, M. Marchionni, and M. Dubois-Dalcq
Neuregulin Signaling Regulates Neural Precursor Growth and the Generation of Oligodendrocytes In Vitro
J. Neurosci., July 1, 2001; 21(13): 4740 - 4751.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. Fallon, S. Reid, R. Kinyamu, I. Opole, R. Opole, J. Baratta, M. Korc, T. L. Endo, A. Duong, G. Nguyen, et al.
In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain
PNAS, December 19, 2000; 97(26): 14686 - 14691.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
N. Uchida, D. W. Buck, D. He, M. J. Reitsma, M. Masek, T. V. Phan, A. S. Tsukamoto, F. H. Gage, and I. L. Weissman
Direct isolation of human central nervous system stem cells
PNAS, December 19, 2000; 97(26): 14720 - 14725.
[Abstract] [Full Text] [PDF]

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 NeuroscientistHome page
F. M. Vaccarino
Stem Cells and Neuronal Progenitors and Their Diversity in the CNS: Are Time and Place Important?
Neuroscientist, October 1, 2000; 6(5): 338 - 352.
[Abstract] [PDF]

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 J. Neurophysiol.Home page
D. R. Piper, T. Mujtaba, M. S. Rao, and M. T. Lucero
Immunocytochemical and Physiological Characterization of a Population of Cultured Human Neural Precursors
J Neurophysiol, July 1, 2000; 84(1): 534 - 548.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
M.-C. Amoureux, B. A. Cunningham, G. M. Edelman, and K. L. Crossin
N-CAM Binding Inhibits the Proliferation of Hippocampal Progenitor Cells and Promotes Their Differentiation to a Neuronal Phenotype
J. Neurosci., May 15, 2000; 20(10): 3631 - 3640.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
R. Y. L. Tsai and R. D. G. McKay
Cell Contact Regulates Fate Choice by Cortical Stem Cells
J. Neurosci., May 15, 2000; 20(10): 3725 - 3735.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
F. H. Gage
Mammalian Neural Stem Cells
Science, February 25, 2000; 287(5457): 1433 - 1438.
[Abstract] [Full Text]

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 J. Neurosci.Home page
M. B. Lachyankar, N. Sultana, C. M. Schonhoff, P. Mitra, W. Poluha, S. Lambert, P. J. Quesenberry, N. S. Litofsky, L. D. Recht, R. Nabi, et al.
A Role for Nuclear PTEN in Neuronal Differentiation
J. Neurosci., February 15, 2000; 20(4): 1404 - 1413.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
D. J. Martens, V. Tropepe, and D. van der Kooy
Separate Proliferation Kinetics of Fibroblast Growth Factor-Responsive and Epidermal Growth Factor-Responsive Neural Stem Cells within the Embryonic Forebrain Germinal Zone
J. Neurosci., February 1, 2000; 20(3): 1085 - 1095.
[Abstract] [Full Text] [PDF]


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