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Journal of Neuroscience, Vol 12, 4737-4744, Copyright © 1992 by Society for Neuroscience
Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development
WH Lee, S Javedan and CA Bondy
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
The interactions of insulin-like growth factors (IGFs) with the type I IGF
receptor are modulated by a family of high-affinity IGF binding proteins
(IGFBPs). One of these, IGFBP2, demonstrates a striking spatiotemporal
relationship with IGF-I during cerebellar and retinal development. IGF-I
mRNA is transiently expressed in large projection neurons--cerebellar
Purkinje and retinal ganglion cells--while IGFBP2 mRNA is selectively
expressed by contiguous neuroglia--Bergmann glia in the cerebellum and
Muller cells and astrocytes of the nerve fiber layer in the retina. IGF-I
and IGFBP2 gene expression is not only neuroanatomically coordinated but
also temporally synchronized, peaking together during the postnatal
maturation of these structures. This pattern of IGF system expression
suggests that IGFBP2 is closely related to IGF-I's action in the developing
nervous system.
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