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Journal of Neuroscience, Vol 12, 4890-4897, Copyright © 1992 by Society for Neuroscience
Myelin acquisition in the central nervous system of the mouse revealed by an MBP-Lac Z transgene
DR Foran and AC Peterson
Department of Neurology and Neurosurgery, and Molecular Oncology, McGill University, Montreal, Quebec, Canada.
Myelin has pronounced effects upon the morphology, function, and growth of
axons in the mammalian CNS. Consequently, oligodendrocyte development and
myelination have been investigated using a wide variety of histological,
immunocytochemical, ultrastructural, and biochemical techniques. While many
of the spatial and temporal features of myelin appearance have been
characterized, for any one species only limited regions of the CNS have
been investigated. To address this limitation, we have derived transgenic
mice in which the bacterial Lac Z gene is regulated by promoter elements of
the myelin basic protein gene. When differentiating oligodendrocytes begin
to elaborate recognizable myelin, they initiate expression of the MBP-Lac Z
transgene and accumulate readily detectable levels of beta-galactosidase.
Here, we exploit the sensitivity, resolution, and ease of
beta-galactosidase histochemical assays to characterize the temporal and
spatial patterns of CNS myelination in the mouse. Many features of the
myelination program revealed by this approach were predicted by the
immunocytochemical and ultrastructural data derived from other species.
Nonetheless, previously undocumented patterns were also encountered.
beta-Galactosidase was expressed first by oligodendrocytes in the ventral
spinal cord, 1 d prior to birth. There, myelination proceeded in a strictly
rostral-caudal direction, whereas in the dorsal cord, myelination initiated
in the cervical enlargement and proceeded in both rostral and caudal
directions. In the cerebellum, deep regions myelinated first, and in the
optic nerve, myelination initiated at the retinal end. In contrast, the
lateral olfactory tracts, pons, and optic chiasm initiated myelination
along their entire course.(ABSTRACT TRUNCATED AT 250 WORDS)
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