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Journal of Neuroscience, Vol 12, 538-548, Copyright © 1992 by Society for Neuroscience
Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies
JA Drewe, S Verma, G Frech and RH Joho
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
Different types of K+ channels play important roles in many aspects of
excitability. The isolation of cDNA clones from Drosophila, Aplysia,
Xenopus, and mammals points to a large multigene family with several
distinct members encoding K+ channels with unique electrophysiological and
pharmacological properties. Given the pivotal role K+ channels play in the
fine tuning of electrical properties of excitable tissues, we studied the
spatial and temporal basis of K+ channel diversity. We report the isolation
of two putative K+ channels that define two new subfamilies based upon
amino acid sequence similarities with other known K+ channels. Northern
blot and in situ hybridization studies revealed differences in the spatial
and temporal expression patterns for these two new clones along with mRNAs
from other K+ channel subfamilies. Two of the K+ channels studied are
predominantly expressed in the brain. One of the "brain-specific" K+
channels is first expressed after about 2 weeks of postnatal cerebellar
development and remains at levels about 10-fold higher in the cerebellum
than in the rest of the brain.
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