WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Discover www.zeiss.de/functionality
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wathey, J. C.
Right arrow Articles by Sejnowski, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wathey, J. C.
Right arrow Articles by Sejnowski, T. J.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 12, 607-618, Copyright © 1992 by Society for Neuroscience

ARTICLE

Computer simulations of EPSP-spike (E-S) potentiation in hippocampal CA1 pyramidal cells

JC Wathey, WW Lytton, JM Jester and TJ Sejnowski
Computational Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186-5800.

Long-term potentiation of hippocampal excitatory synapses is often accompanied by an increase in the probability of spiking to an EPSP of fixed strength (E-S potentiation). We used computer simulations of a CA1 pyramidal neuron to test the plausibility of the hypothesis that E- S potentiation is caused by changes in dendritic excitability. These changes were simulated by adding "hot spots" of noninactivating voltage- sensitive Ca2+ conductance to various dendritic compartments. This typically caused spiking in response to previously subthreshold synaptic inputs. The magnitude of the simulated E-S potentiation depended on the passive electrical properties of the cell, the excitability of the soma, and the relative locations on the dendrites of the synaptic inputs and hot spots. The specificity of the simulated E-S potentiation was quantified by colocalizing the hot spots with a subset (40 of 80) of the synaptic contacts, denoted "tetanized," and then comparing the effects of the hot spots on these and the remaining (untetanized) synaptic contacts. The simulated E-S potentiation tended to be specific to the tetanized input if the untetanized contacts were, on average, electrically closer to the soma than the tetanized contacts. Specificity was also high if the tetanized and untetanized contacts were segregated to different primary dendrites. The results also predict, however, that E-S potentiation by this mechanism will appear to be nonspecific (heterosynaptic) if the synapses of the untetanized input are sufficiently far from the soma relative to the tetanized synapses. Experimental confirmation of this prediction would support the hypothesis that changes in postsynaptic excitability can contribute to hippocampal E-S potentiation.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
E. Campanac, G. Daoudal, N. Ankri, and D. Debanne
Downregulation of Dendritic Ih in CA1 Pyramidal Neurons after LTP
J. Neurosci., August 20, 2008; 28(34): 8635 - 8643.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. Campanac and D. Debanne
Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons
J. Physiol., February 1, 2008; 586(3): 779 - 793.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Xu, N. Kang, L. Jiang, M. Nedergaard, and J. Kang
Activity-Dependent Long-Term Potentiation of Intrinsic Excitability in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., February 16, 2005; 25(7): 1750 - 1760.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. P. Marder and D. V. Buonomano
Timing and Balance of Inhibition Enhance the Effect of Long-Term Potentiation on Cell Firing
J. Neurosci., October 6, 2004; 24(40): 8873 - 8884.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
G. Daoudal and D. Debanne
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms
Learn. Mem., November 1, 2003; 10(6): 456 - 465.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. P. Marder and D. V. Buonomano
Differential Effects of Short- and Long-Term Potentiation on Cell Firing in the CA1 Region of the Hippocampus
J. Neurosci., January 1, 2003; 23(1): 112 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Daoudal, Y. Hanada, and D. Debanne
Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons
PNAS, October 29, 2002; 99(22): 14512 - 14517.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Kimura and C. Pavlides
Long-Term Potentiation/Depotentiation Are Accompanied by Complex Changes in Spontaneous Unit Activity in the Hippocampus
J Neurophysiol, October 1, 2000; 84(4): 1894 - 1906.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Armano, P. Rossi, V. Taglietti, and E. D'Angelo
Long-Term Potentiation of Intrinsic Excitability at the Mossy Fiber-Granule Cell Synapse of Rat Cerebellum
J. Neurosci., July 15, 2000; 20(14): 5208 - 5216.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-