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 Previous Article
Journal of Neuroscience, Vol 12, 674-690, Copyright © 1992 by Society for Neuroscience
Transient calbindin-D28k-positive systems in the telencephalon: ganglionic eminence, developing striatum and cerebral cortex
FC Liu and AM Graybiel
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Calbindin-D28k (calbindin) is a member of the superfamily of calcium-
binding proteins implicated in the regulation of intracellular calcium. In
the mature brain, calbindin is widely expressed in neurons of the forebrain
and the hindbrain, and in the telencephalon calbindin-like immunoreactivity
is particularly strongly expressed by medium-sized neurons of the striatum
and by certain other neurons in the cortex and subcortex. We have traced
the development of calbindin expression in the forebrain of the rat, and
report here that in addition to the steady development of these
calbindin-positive neuronal systems, transient waves of calbindin
expression occur in cells of the ventricular zones of the basal ganglia and
cortex and in cells of the telencephalic regions derived from these
ventricular zones including radial glia of the developing striatum. In the
striatum and its ventricular zone (the ganglionic eminence, or GE) we
identified four transient calbindin-positive systems in the perinatal
period. First, calbindin-immunoreactive cells began to appear in the GE by
embryonic day (E)18, and by E20 an extensive dorsal and lateral part of the
GE was marked by dense calbindin-like immunoreactivity in the ventricular
zone. This calbindin system peaked at postnatal day (P)0-P3 and disappeared
by P15. Its presence suggests that the GE is divisible on a molecular basis
into lateral and medial districts that may correspond to derivatives of the
lateral and medial ventricular ridges. Second, a system of
calbindin-positive processes appeared in the dorsal and lateral
caudoputamen with temporal and spatial distributions matching the germinal
zone system. Many of these processes could be traced from
calbindin-positive cells in the ventricular zone of the GE, including
processes stretching across the full width of the dorsal caudoputamen.
Double-staining experiments demonstrated that these radial processes were
Rat.401-positive, suggesting that they form a subset of radial glia in the
developing telencephalon. These findings demonstrate that during
development calbindin is expressed in glial as well as neural cells. They
further suggest that the radial glia associated with the GE form
heterogeneous populations, the transient calbindin-positive radial glia
being associated with the lateral ridge of the GE and its derivatives.
Third, a scattered population of calbindin-positive cells with morphologies
different from the common medium-sized calbindin- immunoreactive neurons of
the striatum appeared in the dorsal and lateral striatum from about E20 to
P15. Some of these cells were close to the transient calbindin-positive
radial processes in the same region, but others were not.(ABSTRACT
TRUNCATED AT 400 WORDS)
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