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Journal of Neuroscience, Vol 12, 818-826, Copyright © 1992 by Society for Neuroscience
Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength
V Lemmon, SM Burden, HR Payne, GJ Elmslie and ML Hlavin
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106-4975.
Growing axons use environmental cues to guide them to their targets. One
class of cues is thought to be adhesion molecules on cells and in the
extracellular matrix that axons interact with as they grow to their
targets. In choosing between two possible pathways, the relative
adhesiveness of the two substrates could be an important factor in
controlling neurite growth. We conducted experiments in vitro to study how
naturally occurring adhesion molecules influence neurite growth. Neurite
growth rates, the degree of neurite fasciculation, the choices neurites
make between two substrates, and the relative adhesiveness of different
substrates were examined. We found that the relative adhesiveness of a
substrate was a poor predictor of either axon growth rate or the degree of
fasciculation. Furthermore, neurites showed little selectivity between
three different naturally occurring substrates, L1, N-cadherin, and
laminin. These results suggest that some adhesion molecules may serve as
permissive substrates in that they can define axonal pathways but they do
not provide information about which path to take at a choice point or about
which direction to go along the path. Finally, these results suggest that
substrates in vivo may not exert their effects on axon guidance principally
via relative adhesiveness.
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